| http://purl.uniprot.org/citations/31042473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31042473 | http://www.w3.org/2000/01/rdf-schema#comment | "B cell lymphoma-6 (BCL6) is highly expressed in germinal center B cells, but how its expression is maintained is still not completely clear. Aryl hydrocarbon receptor interacting protein (AIP) is a co-chaperone of heat shock protein 90. Deletion of Aip in B cells decreased BCL6 expression, reducing germinal center B cells and diminishing adaptive immune responses. AIP was required for optimal AKT signaling in response to B cell receptor stimulation, and AIP protected BCL6 from ubiquitin-mediated proteasomal degradation by the E3-ubiquitin ligase FBXO11 by binding to the deubiquitinase UCHL1, thus helping to maintain the expression of BCL6. AIP was highly expressed in primary diffuse large B cell lymphomas compared to healthy tissue and other tumors. Our findings describe AIP as a positive regulator of BCL6 expression with implications for the pathobiology of diffuse large B cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.04.014"xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Sun D."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Wan X."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "MacDonald T.T."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Korbonits M."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Buckley C.D."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Aksoy E."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Haworth O."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Capasso M."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Clear A."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Marshall J.L."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Norris S."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Barry S."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Gribben J."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Parsonage G."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Vossenkamper A."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/author | "Stopka-Farooqui U."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/pages | "1461-1471.e4"xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/title | "Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation."xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/31042473 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31042473 |