Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/31042721http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31042721http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Epithelial-mesenchymal transition (EMT) and the histone methyltransferase Enhancer of Zeste Homologue 2 (EZH2) are important regulators of lung cancer progression and metastasis. Although recent studies support the correlation between EZH2 expression and EMT, no reports have investigated their association using immunohistochemistry or explored their prognostic impact on lung adenocarcinoma. The aim of this study was to elucidate the association between EZH2 and EMT, and their prognostic significance.

Methods

EZH2 and the EMT markers E-cadherin and Vimentin were examined by IHC in lung adenocarcinoma specimens that were resected from 2003-2012. Associations between EZH2 and EMT markers and their correlations with survival were analyzed.

Results

We enrolled 350 patients, approximately 70% of whom were diagnosed as pathological stage I. The rates of positive E-cadherin, Vimentin, and EZH2 expression were 60.3%, 21.4%, and 52.0%, respectively. There was a significant positive correlation between EZH2 and Vimentin expression (p = 0.008), and EZH2 scores were higher in the Mesenchymal group (p = 0.030). In multivariate analysis, EZH2 was an independent predictor of Vimentin expression, and vice versa. EMT and EZH2 overexpression were significantly correlated with poor disease-free and overall survival. Furthermore, the Epithelial group with high EZH2 expression had significantly worse disease-free and overall survival. Positive staining for EMT markers was unfavorable regarding disease-free survival among patients with low EZH2 expression.

Conclusions

EMT and high EZH2 expression were associated with poor NSCLC prognoses. Vimentin is a key factor linking EMT and EZH2 in lung adenocarcinoma."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0215103"xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/author"Mori M."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/author"Tagawa T."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/author"Takada K."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/author"Matsubara T."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/author"Toyokawa G."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/author"Shimokawa M."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/author"Kozuma Y."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/author"Haro A."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/author"Osoegawa A."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/author"Akamine T."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/author"Kinoshita F."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/name"PLoS One"xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/pages"e0215103"xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/title"The association and prognostic impact of enhancer of zeste homologue 2 expression and epithelial-mesenchymal transition in resected lung adenocarcinoma."xsd:string
http://purl.uniprot.org/citations/31042721http://purl.uniprot.org/core/volume"14"xsd:string
http://purl.uniprot.org/citations/31042721http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31042721
http://purl.uniprot.org/citations/31042721http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31042721
http://purl.uniprot.org/uniprot/#_F2YMM1-mappedCitation-31042721http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31042721
http://purl.uniprot.org/uniprot/#_A0A0S2Z4T0-mappedCitation-31042721http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31042721
http://purl.uniprot.org/uniprot/#_A0A090N8E9-mappedCitation-31042721http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31042721
http://purl.uniprot.org/uniprot/#_B0YJC4-mappedCitation-31042721http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31042721
▶