| http://purl.uniprot.org/citations/31044621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31044621 | http://www.w3.org/2000/01/rdf-schema#comment | "Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role. Methods: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n = 206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with p values <1 × 10-5 were included in the replication step in three independent cohorts: Haemodynamics in Primary and Secondary Hypertension (DYNAMIC) (n = 182), Finn-Home study (n = 773) and Dietary, Lifestyle and Genetic Determinants of Obesity and Metabolic Syndrome (DILGOM) (n = 182). Results: No single nucleotide polymorphisms reached genome-wide significance for association with either systolic or diastolic WCE. However, two loci provided suggestive evidence for association. A known coronary artery disease risk locus rs2292954 in SPG7 associated with systolic WCE (discovery p value = 2.2 × 10-6, replication p value = 0.03 in Finn-Home, meta-analysis p value 2.6 × 10-4), and rs10033652 in RASGEF1B with diastolic WCE (discovery p value = 4.9 × 10-6, replication p value = 0.04 in DILGOM, meta-analysis p value = 5.0 × 10-3). Conclusion: This study provides evidence for two novel candidate genes, SPG7 and RASGEF1B, associating with WCE. Our results need to be validated in even larger studies carried out in other populations."xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.org/dc/terms/identifier | "doi:10.1080/08037051.2019.1604066"xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/author | "Salomaa V."xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/author | "Kontula K.K."xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/author | "Jula A."xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/author | "Lehtimaki T."xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/author | "Hiltunen T.P."xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/author | "Porsti I.H."xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/author | "Havulinna A."xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/author | "Niiranen T."xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/author | "Rimpela J.M."xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/author | "Tikkakoski A."xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/name | "Blood Press"xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/pages | "239-249"xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/title | "Genome-wide association study of white-coat effect in hypertensive patients."xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/31044621 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31044621 |
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