| http://purl.uniprot.org/citations/31056283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31056283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31056283 | http://www.w3.org/2000/01/rdf-schema#comment | "Varying pH of luminal fluid along the female reproductive tract is a physiological cue that modulates sperm motility. CatSper is a sperm-specific, pH-sensitive calcium channel essential for hyperactivated motility and male fertility. Multi-subunit CatSper channel complexes organize linear Ca2+ signaling nanodomains along the sperm tail. Here, we identify EF-hand calcium-binding domain-containing protein 9 (EFCAB9) as a bifunctional, cytoplasmic machine modulating the channel activity and the domain organization of CatSper. Knockout mice studies demonstrate that EFCAB9, in complex with the CatSper subunit, CATSPERζ, is essential for pH-dependent and Ca2+-sensitive activation of the CatSper channel. In the absence of EFCAB9, sperm motility and fertility is compromised, and the linear arrangement of the Ca2+ signaling domains is disrupted. EFCAB9 interacts directly with CATSPERζ in a Ca2+-dependent manner and dissociates at elevated pH. These observations suggest that EFCAB9 is a long-sought, intracellular, pH-dependent Ca2+ sensor that triggers changes in sperm motility."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2019.03.047"xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2019.03.047"xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Lishko P.V."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Lishko P.V."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Mannowetz N."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Mannowetz N."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Hwang J.Y."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Hwang J.Y."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Bewersdorf J."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Bewersdorf J."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Chung J.J."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Chung J.J."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Everley R.A."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/author | "Everley R.A."xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/31056283 | http://purl.uniprot.org/core/name | "Cell"xsd:string |