| http://purl.uniprot.org/citations/31059511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31059511 | http://www.w3.org/2000/01/rdf-schema#comment | "The transition from mitotic to meiotic cell cycles is essential for haploid gamete formation and fertility. Stimulated by retinoic acid gene 8 (Stra8) is an essential gatekeeper of meiotic initiation in vertebrates; yet, the molecular role of STRA8 remains principally unknown. Here we demonstrate that STRA8 functions as a suppressor of autophagy during spermatogenesis in mice. Stra8-deficient germ cells fail to enter meiosis and present aberrant upregulation of autophagy-lysosome genes, commensurate with autophagy activation. Biochemical assays show that ectopic expression of STRA8 alone is sufficient to inhibit both autophagy induction and maturation. Studies also revealed that, Nr1d1, a nuclear hormone receptor gene, is upregulated in Stra8-deficient testes and that STRA8 binds to the Nr1d1 promoter, indicating that Nr1d1 is a direct target of STRA8 transcriptional repression. In addition, it was found that NR1D1 binds to the promoter of Ulk1, a gene essential for autophagy initiation, and that Nr1d1 is required for the upregulated Ulk1 expression in Stra8-deficient testes. Furthermore, both genetic deletion of Nr1d1 and pharmacologic inhibition of NR1D1 by its synthetic antagonist SR8278 exhibit rescuing effects on the meiotic initiation defects observed in Stra8-deficient male germ cells. Together, the data suggest a novel link between STRA8-mediated autophagy suppression and meiotic initiation."xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1008084"xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/author | "Brown D."xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/author | "Xavier R.J."xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/author | "Lassen K.G."xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/author | "Fung L."xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/author | "Ferder I.C."xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/author | "Capen D."xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/author | "Ohguchi Y."xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/pages | "e1008084"xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/title | "Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice."xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/31059511 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31059511 |
| http://purl.uniprot.org/citations/31059511 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31059511 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JG09-mappedCitation-31059511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31059511 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGA9-mappedCitation-31059511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31059511 |
| http://purl.uniprot.org/uniprot/#_D3Z782-mappedCitation-31059511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31059511 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQN4-mappedCitation-31059511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31059511 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0B3-mappedCitation-31059511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31059511 |
| http://purl.uniprot.org/uniprot/#_E9QAM0-mappedCitation-31059511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31059511 |