| http://purl.uniprot.org/citations/31062247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31062247 | http://www.w3.org/2000/01/rdf-schema#comment | "The Na,K-ATPase, consisting of a catalytic α-subunit and a regulatory β-subunit, is a ubiquitously expressed ion pump that carries out the transport of Na+ and K+ across the plasma membranes of most animal cells. In addition to its pump function, Na,K-ATPase serves as a signaling scaffold and a cell adhesion molecule. Of the three β-subunit isoforms, β1 is found in almost all tissues, while β2 expression is mostly restricted to brain and muscle. In cerebellar granule cells, the β2-subunit, also known as adhesion molecule on glia (AMOG), has been linked to neuron-astrocyte adhesion and granule cell migration, suggesting its role in cerebellar development. Nevertheless, little is known about molecular pathways that link the β2-subunit to its cellular functions. Using cerebellar granule precursor cells, we found that the β2-subunit, but not the β1-subunit, negatively regulates the expression of a key activator of the Hippo/YAP signaling pathway, Merlin/neurofibromin-2 (NF2). The knockdown of the β2-subunit resulted in increased Merlin/NF2 expression and affected downstream targets of Hippo signaling, i.e., increased YAP phosphorylation and decreased expression of N-Ras. Further, the β2-subunit knockdown altered the kinetics of epidermal growth factor receptor (EGFR) signaling in a Merlin-dependent mode and impaired EGF-induced reorganization of the actin cytoskeleton. Therefore, our studies for the first time provide a functional link between the Na,K-ATPase β2-subunit and Merlin/NF2 and suggest a role for the β2-subunit in regulating cytoskeletal dynamics and Hippo/YAP signaling during neuronal differentiation."xsd:string |
| http://purl.uniprot.org/citations/31062247 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12035-019-1592-4"xsd:string |
| http://purl.uniprot.org/citations/31062247 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/31062247 | http://purl.uniprot.org/core/author | "Tokhtaeva E."xsd:string |
| http://purl.uniprot.org/citations/31062247 | http://purl.uniprot.org/core/author | "Vagin O."xsd:string |
| http://purl.uniprot.org/citations/31062247 | http://purl.uniprot.org/core/author | "Kelly P."xsd:string |
| http://purl.uniprot.org/citations/31062247 | http://purl.uniprot.org/core/author | "Langhans S.A."xsd:string |
| http://purl.uniprot.org/citations/31062247 | http://purl.uniprot.org/core/author | "Litan A."xsd:string |
| http://purl.uniprot.org/citations/31062247 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31062247 | http://purl.uniprot.org/core/name | "Mol Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/31062247 | http://purl.uniprot.org/core/pages | "7557-7571"xsd:string |
| http://purl.uniprot.org/citations/31062247 | http://purl.uniprot.org/core/title | "A Functional Interaction Between Na,K-ATPase betapisub>2pi/sub>-Subunit/AMOG and NF2/Merlin Regulates Growth Factor Signaling in Cerebellar Granule Cells."xsd:string |
| http://purl.uniprot.org/citations/31062247 | http://purl.uniprot.org/core/volume | "56"xsd:string |
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