| http://purl.uniprot.org/citations/31063232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31063232 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNA-26a-5p (miR-26a-5p) has been reported to be involved in the tumorigenesis of several tumors, but its function in breast cancer is still unknown. In this study, miR-26a-5p was found significantly downregulated in both of the breast cancer tissues and cell lines, and low expression of miR-26a-5p predicted a poor prognosis for breast cancer patients. Overexpression of miR-26a-5p could significantly inhibit breast cancer cell growth. Further studies revealed that overexpression of miR-26a-5p downregulated the protein levels of Cyclin D1, CDK4, and CDK6, but upregulated the expression levels of p21, p27, and p53. In mechanism, miR-26a-5p targeted the 3'UTR of ring finger protein 6 (RNF6) mRNA and inhibited RNF6 expression in breast cancer cells. Moreover, overexpression of miR-26a-5p inhibited RNF6/ERα/Bcl-xL axis in breast cancer cells. In contrast, inhibiting miR-26a-5p upregulated RNF6/ERα/Bcl-xL axis. Further studies indicated that miR-26a-5p mediated RNF6/ERα/Bcl-xL axis through regulating the stability of ERα protein. Collectively, downregulation of miR-26a-5p plays essential roles in breast cancer by mediating RNF6/ERα/Bcl-xL axis, which might provide important implications for the therapeutics of breast cancer."xsd:string |
| http://purl.uniprot.org/citations/31063232 | http://purl.org/dc/terms/identifier | "doi:10.1002/kjm2.12085"xsd:string |
| http://purl.uniprot.org/citations/31063232 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/31063232 | http://purl.uniprot.org/core/author | "Cai Y."xsd:string |
| http://purl.uniprot.org/citations/31063232 | http://purl.uniprot.org/core/author | "Yang C.C."xsd:string |
| http://purl.uniprot.org/citations/31063232 | http://purl.uniprot.org/core/author | "Huang Z.M."xsd:string |
| http://purl.uniprot.org/citations/31063232 | http://purl.uniprot.org/core/author | "Tao J.L."xsd:string |
| http://purl.uniprot.org/citations/31063232 | http://purl.uniprot.org/core/author | "Ge H.F."xsd:string |
| http://purl.uniprot.org/citations/31063232 | http://purl.uniprot.org/core/author | "Tian W.Z."xsd:string |
| http://purl.uniprot.org/citations/31063232 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31063232 | http://purl.uniprot.org/core/name | "Kaohsiung J Med Sci"xsd:string |
| http://purl.uniprot.org/citations/31063232 | http://purl.uniprot.org/core/pages | "467-473"xsd:string |
| http://purl.uniprot.org/citations/31063232 | http://purl.uniprot.org/core/title | "MicroRNA-26a-5p inhibits breast cancer cell growth by suppressing RNF6 expression."xsd:string |
| http://purl.uniprot.org/citations/31063232 | http://purl.uniprot.org/core/volume | "35"xsd:string |
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