| http://purl.uniprot.org/citations/31066027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31066027 | http://www.w3.org/2000/01/rdf-schema#comment | "Carbamazepine (CBZ) causes life-threating T-cell-mediated hypersensitivity reactions, including serious cutaneous adverse reactions (SCARs) and drug-induced liver injury (CBZ-DILI). In order to evaluate shared or phenotype-specific genetic predisposing factors for CBZ hypersensitivity reactions, we performed a meta-analysis of two genomewide association studies (GWAS) on a total of 43 well-phenotyped Northern and Southern European CBZ-SCAR cases and 10,701 population controls and a GWAS on 12 CBZ-DILI cases and 8,438 ethnically matched population controls. HLA-A*31:01 was identified as the strongest genetic predisposing factor for both CBZ-SCAR (odds ratio (OR) = 8.0; 95% CI 4.10-15.80; P = 1.2 × 10-9 ) and CBZ-DILI (OR = 7.3; 95% CI 2.47-23.67; P = 0.0004) in European populations. The association with HLA-A*31:01 in patients with SCAR was mainly driven by hypersensitivity syndrome (OR = 12.9; P = 2.1 × 10-9 ) rather than by Stevens-Johnson syndrome/toxic epidermal necrolysis cases, which showed an association with HLA-B*57:01. We also identified a novel risk locus mapping to ALK only for CBZ-SCAR cases, which needs replication in additional cohorts and functional evaluation."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.org/dc/terms/identifier | "doi:10.1002/cpt.1493"xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Daly M.J."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Barrett S."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Stephens C."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Laitinen T."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Nelson M.R."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Romano A."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Daly A.K."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Marson A."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Morris A.P."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Phillips E."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Floratos A."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Watkins P.B."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Pirmohamed M."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Alfirevic A."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Molokhia M."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Pichler W."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Wadelius M."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "McEvoy L."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Hallberg P."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Andrade R.J."xsd:string |
| http://purl.uniprot.org/citations/31066027 | http://purl.uniprot.org/core/author | "Lucena M.I."xsd:string |