| http://purl.uniprot.org/citations/31066147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31066147 | http://www.w3.org/2000/01/rdf-schema#comment | "The early postnatal stage is a critical period of hippocampal neurodevelopment and also a period of high vulnerability to adverse life experiences. Recent evidence suggests that nectin-3, a cell adhesion molecule, mediates memory dysfunction and dendritic alterations in the adult hippocampus induced by postnatal stress. But it is unknown whether postnatal nectin-3 reduction alone is sufficient to alter hippocampal structure and function in adulthood. Here, we down regulated hippocampal expression of nectin-3 and its heterophilic adhesion partner nectin-1, respectively, from early postnatal stage by injecting adeno-associated virus (AAV) into the cerebral lateral ventricles of neonatal mice (postnatal day 2). We found that suppression of nectin-3, but not nectin-1, expression from the early postnatal stage impaired hippocampus-dependent novel object recognition and spatial object recognition in adult mice. Moreover, AAV-mediated nectin-3 knockdown significantly reduced dendritic complexity and spine density of pyramidal neurons throughout the hippocampus, whereas nectin-1 knockdown only induced the loss of stubby spines in CA3. Our data provide direct evidence that nectins, especially nectin-3, are necessary for postnatal hippocampal development of memory functions and structural integrity."xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.org/dc/terms/identifier | "doi:10.1002/hipo.23098"xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/author | "Liu R."xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/author | "Sun Y.X."xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/author | "Wang X.D."xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/author | "Wang H.L."xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/author | "Su Y.A."xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/author | "Li J.T."xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/author | "Si T.M."xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/name | "Hippocampus"xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/pages | "1063-1074"xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/title | "Postnatal nectin-3 knockdown induces structural abnormalities of hippocampal principal neurons and memory deficits in adult mice."xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/31066147 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31066147 |
| http://purl.uniprot.org/citations/31066147 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31066147 |
| http://purl.uniprot.org/uniprot/#_D3YWA3-mappedCitation-31066147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31066147 |
| http://purl.uniprot.org/uniprot/#_F6UII7-mappedCitation-31066147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31066147 |
| http://purl.uniprot.org/uniprot/#_D3Z657-mappedCitation-31066147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31066147 |
| http://purl.uniprot.org/uniprot/#_D3Z6X5-mappedCitation-31066147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31066147 |
| http://purl.uniprot.org/uniprot/#_F7A4R2-mappedCitation-31066147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31066147 |
| http://purl.uniprot.org/uniprot/#_Q9JLB9-mappedCitation-31066147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31066147 |
| http://purl.uniprot.org/uniprot/Q9JLB9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31066147 |