| http://purl.uniprot.org/citations/31066677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31066677 | http://www.w3.org/2000/01/rdf-schema#comment | "Beta-catenin (i.e., canonical Wnt) signaling controls CNS angiogenesis and the blood-brain and blood-retina barriers. To explore the role of the Discs large/membrane-associated guanylate kinase (Dlg/MAGUK) family of scaffolding proteins in beta-catenin signaling, we studied vascular endothelial cell (EC)-specific knockout of Dlg1/SAP97. EC-specific loss of Dlg1 produces a retinal vascular phenotype that closely matches the phenotype associated with reduced beta-catenin signaling, synergizes with genetically-directed reductions in beta-catenin signaling components, and can be rescued by stabilizing beta-catenin in ECs. In reporter cells with CRISPR/Cas9-mediated inactivation of Dlg1, transfection of Dlg1 enhances beta-catenin signaling ~4 fold. Surprisingly, Frizzled4, which contains a C-terminal PDZ-binding motif that can bind to Dlg1 PDZ domains, appears to function independently of Dlg1 in vivo. These data expand the repertoire of Dlg/MAGUK family functions to include a role in beta-catenin signaling, and they suggest that proteins other than Frizzled receptors interact with Dlg1 to enhance beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/31066677 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.45542"xsd:string |
| http://purl.uniprot.org/citations/31066677 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/31066677 | http://purl.uniprot.org/core/author | "Williams J."xsd:string |
| http://purl.uniprot.org/citations/31066677 | http://purl.uniprot.org/core/author | "Nathans J."xsd:string |
| http://purl.uniprot.org/citations/31066677 | http://purl.uniprot.org/core/author | "Smallwood P.M."xsd:string |
| http://purl.uniprot.org/citations/31066677 | http://purl.uniprot.org/core/author | "Cho C."xsd:string |
| http://purl.uniprot.org/citations/31066677 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31066677 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/31066677 | http://purl.uniprot.org/core/pages | "e45542"xsd:string |
| http://purl.uniprot.org/citations/31066677 | http://purl.uniprot.org/core/title | "Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers."xsd:string |
| http://purl.uniprot.org/citations/31066677 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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