| http://purl.uniprot.org/citations/31070778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31070778 | http://www.w3.org/2000/01/rdf-schema#comment | "Cortical interneurons are derived from the subcortical medial ganglionic eminence (MGE), caudal ganglionic eminence (CGE) and preoptic area (POA). CGE-derived cortical interneurons, which comprise around 30% of all cortical interneurons, mainly express Htr3a, calretinin (CR), Reelin (RELN) and vasoactive intestinal polypeptide (VIP). In the present study, we show that transcription factors Sp8 and Sp9 are co-expressed in the subventricular zone (SVZ) of the dorsal CGE. Conditional knockout of Sp8/9 using the Gsx2-Cre transgenic line results in severe loss of CGE-derived cortical interneurons. We observed migration defects of Sp8/9 double mutant CGE-derived cortical interneurons as they had longer leading processes than controls and they ectopically accumulated in the CGE. Dlx5/6-CIE conditional deletion of Sp8/9 also leads to a significant reduction in the CGE-derived cortical interneurons. We provide evidence that Sp8/9 coordinately regulate CGE-derived cortical interneuron development in part through repressing the expression of Pak3, Robo1, and Slit1. Finally, we show that Cxcl14, a member of the CXC chemokine family, is mainly expressed in CGE-derived interneurons in cortical layers I and II, and its expression is critically dependent on SP8."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.24712"xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Du H."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Liu G."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Su Z."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Wen Y."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "You Y."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Wei S."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Shang Z."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/author | "Tao G."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/name | "J Comp Neurol"xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/pages | "2860-2874"xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/title | "Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons."xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://purl.uniprot.org/core/volume | "527"xsd:string |
| http://purl.uniprot.org/citations/31070778 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31070778 |
| http://purl.uniprot.org/citations/31070778 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31070778 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNW8-mappedCitation-31070778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31070778 |