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http://purl.uniprot.org/citations/3107551http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/3107551http://www.w3.org/2000/01/rdf-schema#comment"The intracellular function of a specific protein to protect lysosomal beta-galactosidase and neuraminidase activities against proteases in human fibroblasts was studied. Beta-Galactosidase was purified from human placenta to different degrees; a preparation (A) contained also two concomitant proteins, and a highly purified preparation (B) contained only the mature beta-galactosidase. The protein concentrate of the culture medium of normal fibroblasts restored the activities of the deficient enzymes, beta-galactosidase and neuraminidase, in galactosialidosis cells. This effect was inhibited only by the anti-A anti-serum, and not by the anti-B antiserum. A 46-kilodalton protein, secreted from fibroblasts cultured in the presence of ammonium chloride, was detected again only by the anti-A antiserum, and not by the anti-B antiserum. It was concluded that this protein has a function to restore their activities in fibroblasts from galactosialidosis patients after being endocytosed from the culture medium."xsd:string
http://purl.uniprot.org/citations/3107551http://purl.org/dc/terms/identifier"doi:10.1016/s0006-291x(87)80486-2"xsd:string
http://purl.uniprot.org/citations/3107551http://purl.uniprot.org/core/author"Suzuki Y."xsd:string
http://purl.uniprot.org/citations/3107551http://purl.uniprot.org/core/author"Tsuji A."xsd:string
http://purl.uniprot.org/citations/3107551http://purl.uniprot.org/core/author"Nanba E."xsd:string
http://purl.uniprot.org/citations/3107551http://purl.uniprot.org/core/author"Omura K."xsd:string
http://purl.uniprot.org/citations/3107551http://purl.uniprot.org/core/date"1987"xsd:gYear
http://purl.uniprot.org/citations/3107551http://purl.uniprot.org/core/name"Biochem Biophys Res Commun"xsd:string
http://purl.uniprot.org/citations/3107551http://purl.uniprot.org/core/pages"138-142"xsd:string
http://purl.uniprot.org/citations/3107551http://purl.uniprot.org/core/title"Galactosialidosis: a direct evidence that a 46-kilodalton protein restores deficient enzyme activities in fibroblasts."xsd:string
http://purl.uniprot.org/citations/3107551http://purl.uniprot.org/core/volume"144"xsd:string
http://purl.uniprot.org/citations/3107551http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/3107551
http://purl.uniprot.org/citations/3107551http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/3107551
http://purl.uniprot.org/uniprot/P10619#attribution-941EBCCF6640B296E4888598FFFE78B9http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/3107551