| http://purl.uniprot.org/citations/31076555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31076555 | http://www.w3.org/2000/01/rdf-schema#comment | "New therapeutic strategies targeting influenza are actively sought due to limitations in current drugs available. Host-directed therapy is an emerging concept to target host functions involved in pathogen life cycles and/or pathogenesis, rather than pathogen components themselves. From this perspective, we focused on an essential host partner of influenza viruses, the RED-SMU1 splicing complex. Here, we identified two synthetic molecules targeting an α-helix/groove interface essential for RED-SMU1 complex assembly. We solved the structure of the SMU1 N-terminal domain in complex with RED or bound to one of the molecules identified to disrupt this complex. We show that these compounds inhibiting RED-SMU1 interaction also decrease endogenous RED-SMU1 levels and inhibit viral mRNA splicing and viral multiplication, while preserving cell viability. Overall, our data demonstrate the potential of RED-SMU1 destabilizing molecules as an antiviral therapy that could be active against a wide range of influenza viruses and be less prone to drug resistance."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1901214116"xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Fournier G."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "McCarthy A.A."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Vidalain P.O."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Pietrancosta N."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Jacob Y."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Rameix-Welti M.A."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Ruigrok R.W.H."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Naffakh N."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Crepin T."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Gravier-Pelletier C."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Le Corre L."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Ashraf U."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Tengo L."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/author | "Busca P."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/pages | "10968-10977"xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/title | "Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy."xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/31076555 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31076555 |
| http://purl.uniprot.org/citations/31076555 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31076555 |
| http://purl.uniprot.org/uniprot/#_A0MNN4-mappedCitation-31076555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31076555 |