| http://purl.uniprot.org/citations/31078730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31078730 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxidative stress and effector memory CD8+ T cells have been greatly implicated in vitiligo pathogenesis. However, the crosstalk between these two crucial pathogenic factors has been merely investigated. IL-15 has been regarded as an important cytokine exerting its facilitative effect on memory CD8+ T cells function in various autoimmune diseases. In the present study, we initially discovered that the IL-15 expression was significantly increased in vitiligo epidermis and highly associated with epidermal H2O2 content. In addition, epidermal IL-15 expression was mainly derived from keratinocytes. Then, we showed that oxidative stress promoted IL-15 and IL-15Rα expression as well as IL-15 trans-presentation by activating NF-κB signaling in keratinocytes. What's more, the trans-presented IL-15, rather than the secreted one, was accounted for the potentiation of CD8+ TEMs activation. We further investigated the mechanism underlying trans-presented IL-15 in potentiating CD8+ TEMs activation and found that the blockage of IL-15-JAK-STAT signaling could be a potent therapeutic approach. Taken together, our results demonstrate that oxidative stress-induced IL-15 trans-presentation in keratinocytes contributes to the activation of CD8+ TEMs, providing a novel mechanism by which oxidative stress initiates autoimmunity in vitiligo."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.freeradbiomed.2019.05.011"xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Guo W."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Guo S."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Gao T."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Xiao Q."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Cui T."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Chang Y."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Yi X."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Jian Z."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/author | "Kang P."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/name | "Free Radic Biol Med"xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/pages | "80-91"xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/title | "Oxidative stress-induced IL-15 trans-presentation in keratinocytes contributes to CD8+ T cells activation via JAK-STAT pathway in vitiligo."xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://purl.uniprot.org/core/volume | "139"xsd:string |
| http://purl.uniprot.org/citations/31078730 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31078730 |
| http://purl.uniprot.org/citations/31078730 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31078730 |