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http://purl.uniprot.org/citations/31081088http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31081088http://www.w3.org/2000/01/rdf-schema#comment"

Objective

MicroRNAs (miRNAs) affect almost all cell behaviors of human cancers including gastric cancer (GC). However, the biological role of miR-411 in GC remains to be elucidated.

Materials and methods

We determined the expression level of miR-411 in GC cell lines. After synthetic miRNAs or SET domain containing 6 (SETD6) expression vectors transfection, cell proliferation, colony formation, and migration were examined. Moreover, the target of miR-411 was identified by luciferase activity reporter assay and Western blot assay.

Results

Results revealed that the miR-411 expression was significantly down-regulated in GC cell lines compared with normal colonic epithelial cells. Overexpression of miR-411 inhibits GC cell proliferation, colony formation, and migration, whereas the overexpression of SETD6 promotes cell proliferation, colony formation, and migration. Moreover, SETD6 was identified as a putative target of miR-411. In addition, we showed miR-411 regulates GC cell behaviors by targeting SETD6. The overexpression of SETD6 promoted the activation of the nuclear factor (NF)-κB signaling pathway.

Conclusions

These results suggested that miR-411 functions as a tumor suppressor in GC through targeting SETD6/NF-κB pathway. Targeting miR-411 may be a novel clue for GC treatment."xsd:string
http://purl.uniprot.org/citations/31081088http://purl.org/dc/terms/identifier"doi:10.26355/eurrev_201904_17697"xsd:string
http://purl.uniprot.org/citations/31081088http://purl.uniprot.org/core/author"Liu Y.B."xsd:string
http://purl.uniprot.org/citations/31081088http://purl.uniprot.org/core/author"Li B.H."xsd:string
http://purl.uniprot.org/citations/31081088http://purl.uniprot.org/core/author"Bai T.L."xsd:string
http://purl.uniprot.org/citations/31081088http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31081088http://purl.uniprot.org/core/name"Eur Rev Med Pharmacol Sci"xsd:string
http://purl.uniprot.org/citations/31081088http://purl.uniprot.org/core/pages"3344-3350"xsd:string
http://purl.uniprot.org/citations/31081088http://purl.uniprot.org/core/title"MiR-411 inhibits gastric cancer proliferation and migration through targeting SETD6."xsd:string
http://purl.uniprot.org/citations/31081088http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/31081088http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31081088
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