| http://purl.uniprot.org/citations/31081901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31081901 | http://www.w3.org/2000/01/rdf-schema#comment | "Innate-like B-1a cells are an important cell population for production of natural IgM and interleukin-10 (IL-10), and act as the first line against pathogens. We determined that CMTM7 is essential for B-1a cell development. Following Cmtm7 (CKLF-like MARVEL transmembrane domain-containing 7) knockout, B-1a cell numbers decreased markedly in all investigated tissues. Using a bone marrow and fetal liver adoptive transfer model and conditional knockout mice, we showed that the reduction of B-1a cells resulted from B-cell-intrinsic defects. Because of B-1a cell loss, Cmtm7-deficient mice produced less IgM and IL-10, and were more susceptible to microbial sepsis. Self-renewal and homeostasis of mature B-1a cells in Cmtm7-/-mice were not impaired, suggesting the effect of Cmtm7 on B-1a cell development. Further investigations demonstrated that the function of Cmtm7 in B-1a cell development occurred at the specific transitional B-1a (TrB-1a) stage. Cmtm7 deficiency resulted in a slow proliferation and high cell death rate of TrB-1a cells. Thus, Cmtm7 controls B-1a cell development at the transitional stage."xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxz041"xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/author | "Han W."xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/author | "Ma D."xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/author | "Mo X."xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/author | "Ge Q."xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/author | "Lv P."xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/pages | "715-728"xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/title | "Cmtm7 knockout inhibits B-1a cell development at the transitional (TrB-1a) stage."xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/31081901 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31081901 |
| http://purl.uniprot.org/citations/31081901 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31081901 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SRR1-mappedCitation-31081901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31081901 |
| http://purl.uniprot.org/uniprot/#_Q3THH0-mappedCitation-31081901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31081901 |
| http://purl.uniprot.org/uniprot/#_Q3TI37-mappedCitation-31081901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31081901 |
| http://purl.uniprot.org/uniprot/#_Q3U9H9-mappedCitation-31081901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31081901 |
| http://purl.uniprot.org/uniprot/#_Q3TIE7-mappedCitation-31081901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31081901 |
| http://purl.uniprot.org/uniprot/#_Q9ESD6-mappedCitation-31081901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31081901 |