| http://purl.uniprot.org/citations/31084489 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31084489 | http://www.w3.org/2000/01/rdf-schema#comment | "Fetuin-A (Fet-A), a hepatokine associated with insulin resistance, obesity, and incident type 2 diabetes, is shown to exist in both phosphorylated and dephosphorylated forms in circulation. However, studies on fetuin-A phosphorylation status in insulin-resistant conditions and its functional significance are limited. We demonstrate that serum phosphofetuin-A (Ser312) levels were significantly elevated in high-fat diet-induced obese mice, insulin-resistant Zucker diabetic fatty rats, and in individuals with obesity who are insulin resistant. Unlike serum total fetuin-A, serum phosphofetuin-A was associated with body weight, insulin, and markers of insulin resistance. To characterize potential mechanisms, fetuin-A was purified from Hep3B human hepatoma cells. Hep3B Fet-A was phosphorylated (Ser312) and inhibited insulin-stimulated glucose uptake and glycogen synthesis in L6GLUT4 myoblasts. Furthermore, single (Ser312Ala) and double (Ser312Ala + Ser120Ala) phosphorylation-defective Fet-A mutants were without effect on glucose uptake and glycogen synthesis in L6GLUT4 myoblasts. Together, our studies demonstrate that phosphorylation status of Fet-A (Ser312) is associated with obesity and insulin resistance and raise the possibility that Fet-A phosphorylation may play a role in regulation of insulin action."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpendo.00089.2018"xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Ren G."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Kim T."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Bilan P.J."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Mathews S.T."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Zaid H."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Papizan J.B."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Araya-Ramirez F."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Bowers R.L."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Grandjean P.W."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Kothari V.M."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Littlefield L.A."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Ludvigsen R."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Mahurin A.J."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Nickles M.M."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/author | "Okerberg C.K."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/name | "Am J Physiol Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/pages | "E250-E260"xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/title | "Phosphorylation status of fetuin-A is critical for inhibition of insulin action and is correlated with obesity and insulin resistance."xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://purl.uniprot.org/core/volume | "317"xsd:string |
| http://purl.uniprot.org/citations/31084489 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31084489 |