| http://purl.uniprot.org/citations/31086178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31086178 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia signaling plays a major role in non-malignant and malignant hyperproliferative diseases. Pulmonary hypertension (PH), a hypoxia-driven vascular disease, is characterized by a glycolytic switch similar to the Warburg effect in cancer. Ras association domain family 1A (RASSF1A) is a scaffold protein that acts as a tumour suppressor. Here we show that hypoxia promotes stabilization of RASSF1A through NOX-1- and protein kinase C-dependent phosphorylation. In parallel, hypoxia inducible factor-1 α (HIF-1α) activates RASSF1A transcription via HIF-binding sites in the RASSF1A promoter region. Vice versa, RASSF1A binds to HIF-1α, blocks its prolyl-hydroxylation and proteasomal degradation, and thus enhances the activation of the glycolytic switch. We find that this mechanism operates in experimental hypoxia-induced PH, which is blocked in RASSF1A knockout mice, in human primary PH vascular cells, and in a subset of human lung cancer cells. We conclude that RASSF1A-HIF-1α forms a feedforward loop driving hypoxia signaling in PH and cancer."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-10044-z"xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Meister M."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Samakovlis C."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Grimminger F."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Weissmann N."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Semenza G.L."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Seeger W."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Muley T."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Wietelmann A."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Savai R."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Pullamsetti S.S."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Dabral S."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Seeger-Nukpezah T."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Muecke C."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Valasarajan C."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/author | "Schmoranzer M."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/pages | "2130"xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/title | "A RASSF1A-HIF1alpha loop drives Warburg effect in cancer and pulmonary hypertension."xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31086178 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31086178 |
| http://purl.uniprot.org/citations/31086178 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31086178 |