| http://purl.uniprot.org/citations/31086255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31086255 | http://www.w3.org/2000/01/rdf-schema#comment | "NF-κB, a family of transcription factors regulating diverse biological processes including immune responses, is activated by canonical and noncanonical pathways based on degradation of IκBα and processing of the IκB-like protein p100, respectively. Although p100 responds to noncanonical NF-κB stimuli for processing, it does not undergo degradation, but rather becomes accumulated, along with canonical NF-κB activation. We show here that the stability of p100 is tightly controlled by a deubiquitinase, Otub1. Otub1 deficiency not only promotes signal-induced p100 processing and noncanonical NF-κB activation but also causes steady-state p100 degradation, leading to aberrant NF-κB activation in the canonical pathway. B-cell-conditional deletion of Otub1 results in B-cell hyperplasia, antibody hyper-production, and lupus-like autoimmunity. Otub1-deficient B cells display aberrantly activated phenotypes and overproduce the cytokine IL-6, contributing to autoimmunity induction. Thus, maintenance of p100 stability by Otub1 serves as an unusual mechanism of NF-κB regulation that prevents autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41422-019-0174-3"xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Cheng X."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Gu M."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Jain A."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Lin D."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Xie X."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Yang J.Y."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Li H.S."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Sun S.C."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Watowich S.S."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Jie Z."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/author | "Yun Jung S."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/name | "Cell Res"xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/pages | "474-485"xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/title | "Preventing abnormal NF-kappaB activation and autoimmunity by Otub1-mediated p100 stabilization."xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/31086255 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31086255 |