| http://purl.uniprot.org/citations/31090539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31090539 | http://www.w3.org/2000/01/rdf-schema#comment | "Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse models, the role for IFNγ signaling in human antibody responses is unknown. We show that elevated levels of IFNγ in SLE patients correlate with expansion of the T-bet expressing IgDnegCD27negCD11c+CXCR5neg (DN2) pre-antibody secreting cell (pre-ASC) subset. We demonstrate that naïve B cells form T-bethi pre-ASCs following stimulation with either Th1 cells or with IFNγ, IL-2, anti-Ig and TLR7/8 ligand and that IL-21 dependent ASC formation is significantly enhanced by IFNγ or IFNγ-producing T cells. IFNγ promotes ASC development by synergizing with IL-2 and TLR7/8 ligands to induce genome-wide epigenetic reprogramming of B cells, which results in increased chromatin accessibility surrounding IRF4 and BLIMP1 binding motifs and epigenetic remodeling of IL21R and PRDM1 loci. Finally, we show that IFNγ signals poise B cells to differentiate by increasing their responsiveness to IL-21."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.41641"xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Danila M.I."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Stone S.L."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Schoeb T.R."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Mousseau B."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Boss J.M."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Sanz I."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Lund F.E."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Kimberly R.P."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Chatham W.W."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Bradley J.E."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Edberg J.C."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Botta D."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Rosenberg A.F."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Wojciechowski W."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Ptacek T."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Bridges S.L. Jr."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Scharer C.D."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Jenks S.A."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Nellore A."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Rosal-Vela A."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/author | "Zumaquero E."xsd:string |
| http://purl.uniprot.org/citations/31090539 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |