| http://purl.uniprot.org/citations/31097581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31097581 | http://www.w3.org/2000/01/rdf-schema#comment | "Vitamin A is a dietary component that is essential for the development of intestinal immunity. Vitamin A is absorbed and converted to its bioactive derivatives retinol and retinoic acid by the intestinal epithelium, yet little is known about how epithelial cells regulate vitamin A-dependent intestinal immunity. Here we show that epithelial cell expression of the transcription factor retinoic acid receptor β (RARβ) is essential for vitamin A-dependent intestinal immunity. Epithelial RARβ activated vitamin A-dependent expression of serum amyloid A (SAA) proteins by binding directly to Saa promoters. In accordance with the known role of SAAs in regulating Th17 cell effector function, epithelial RARβ promoted IL-17 production by intestinal Th17 cells. More broadly, epithelial RARβ was required for the development of key vitamin A-dependent adaptive immune responses, including CD4+ T-cell homing to the intestine and the development of IgA-producing intestinal B cells. Our findings provide insight into how the intestinal epithelium senses dietary vitamin A status to regulate adaptive immunity, and highlight the role of epithelial cells in regulating intestinal immunity in response to diet."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1812069116"xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/author | "Hooper L.V."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/author | "Sockanathan S."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/author | "Kuang Z."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/author | "Bang Y.J."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/author | "Ruhn K.A."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/author | "Pendse M."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/author | "Harris T.A."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/author | "Dende C."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/author | "Gattu S."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/author | "Chara A.L."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/pages | "10911-10916"xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/title | "Epithelial retinoic acid receptor beta regulates serum amyloid A expression and vitamin A-dependent intestinal immunity."xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/31097581 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31097581 |
| http://purl.uniprot.org/citations/31097581 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31097581 |
| http://purl.uniprot.org/uniprot/#_A0A286YCX1-mappedCitation-31097581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31097581 |
| http://purl.uniprot.org/uniprot/#_A0A286YDP5-mappedCitation-31097581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31097581 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV5-mappedCitation-31097581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31097581 |
| http://purl.uniprot.org/uniprot/#_A0A286YE15-mappedCitation-31097581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31097581 |