| http://purl.uniprot.org/citations/31100268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31100268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31100268 | http://www.w3.org/2000/01/rdf-schema#comment | "Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts with most influenza A viruses. Structural characterization of FluA-20 with H1 and H3 head domains revealed a novel epitope in the HA trimer interface, suggesting previously unrecognized dynamic features of the trimeric HA protein. The critical HA residues recognized by FluA-20 remain conserved across most subtypes of influenza A viruses, which explains the Ab's extraordinary breadth. The Ab rapidly disrupted the integrity of HA protein trimers, inhibited cell-to-cell spread of virus in culture, and protected mice against challenge with viruses of H1N1, H3N2, H5N1, or H7N9 subtypes when used as prophylaxis or therapy. The FluA-20 Ab has uncovered an exceedingly conserved protective determinant in the influenza HA head domain trimer interface that is an unexpected new target for anti-influenza therapeutics and vaccines."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2019.04.011"xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2019.04.011"xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Lang S."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Lang S."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Garcia-Sastre A."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Garcia-Sastre A."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Ward A.B."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Ward A.B."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Crowe J.E. Jr."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Turner H.L."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Turner H.L."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Schotsaert M."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Schotsaert M."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Crowe J.E."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Kose N."xsd:string |
| http://purl.uniprot.org/citations/31100268 | http://purl.uniprot.org/core/author | "Kose N."xsd:string |