| http://purl.uniprot.org/citations/31101919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31101919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31101919 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently demonstrated that mammalian cells harbor nicotinamide adenine dinucleotide (NAD)-capped messenger RNAs that are hydrolyzed by the DXO deNADding enzyme. Here, we report that the Nudix protein Nudt12 is a second mammalian deNADding enzyme structurally and mechanistically distinct from DXO and targeting different RNAs. The crystal structure of mouse Nudt12 in complex with the deNADding product AMP and three Mg2+ ions at 1.6 Å resolution provides insights into the molecular basis of the deNADding activity in the NAD pyrophosphate. Disruption of the Nudt12 gene stabilizes transfected NAD-capped RNA in cells, and its endogenous NAD-capped mRNA targets are enriched in those encoding proteins involved in cellular energetics. Furthermore, exposure of cells to nutrient or environmental stress manifests changes in NAD-capped RNA levels that are selectively responsive to Nudt12 or DXO, respectively, indicating an association of deNADding to cellular metabolism."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41589-019-0293-7"xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41589-019-0293-7"xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Tong L."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Tong L."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Mateyak M.K."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Mateyak M.K."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Cui H."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Cui H."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Jiao X."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Jiao X."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Grudzien-Nogalska E."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Grudzien-Nogalska E."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Kiledjian M."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Kiledjian M."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Hart R.P."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/author | "Hart R.P."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/name | "Nat. Chem. Biol."xsd:string |
| http://purl.uniprot.org/citations/31101919 | http://purl.uniprot.org/core/name | "Nat. Chem. Biol."xsd:string |