| http://purl.uniprot.org/citations/31103264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31103264 | http://www.w3.org/2000/01/rdf-schema#comment | "POU domain class 2-associating factor 1 (also called Bob1), which is mainly expressed in B cells, regulates B cell homeostasis and controls humoral immune responses. Although Bob1 is known to function reliably in T cell subsets including follicular helper T cells, Th1 cells and Th2 cells, it is unknown whether Bob1 functions in other T cell subsets. In this study, we found that Bob1 knock out (KO) mice are resistant to experimental autoimmune encephalomyelitis (EAE) induced by MOG35-55 peptide and that Bob1 KO T cells are defective in Th17 differentiation. Importantly, Bob1 interacts with retinoid acid receptor-related orphan receptor (ROR) gamma t (RORγt), a signature transcription factor for Th17 cells, through the ligand-binding domain of RORγt, thereby enhancing IL-17A transcription activity. IL-17A induction by Bob1 requires the ability for its formation of a DNA-Oct1-Bobl ternary complex. Thus, our findings demonstrate that Bob1 enhances IL-17A expression in vivo and in vitro by interacting with RORγt in Th17 cells, suggesting that Bob1 plays a pivotal role in Th17-mediated autoimmune disease."xsd:string |
| http://purl.uniprot.org/citations/31103264 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2019.05.057"xsd:string |
| http://purl.uniprot.org/citations/31103264 | http://purl.uniprot.org/core/author | "Kamiya S."xsd:string |
| http://purl.uniprot.org/citations/31103264 | http://purl.uniprot.org/core/author | "Ikegami I."xsd:string |
| http://purl.uniprot.org/citations/31103264 | http://purl.uniprot.org/core/author | "Ichimiya S."xsd:string |
| http://purl.uniprot.org/citations/31103264 | http://purl.uniprot.org/core/author | "Takaki H."xsd:string |
| http://purl.uniprot.org/citations/31103264 | http://purl.uniprot.org/core/author | "Kamekura R."xsd:string |
| http://purl.uniprot.org/citations/31103264 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31103264 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/31103264 | http://purl.uniprot.org/core/pages | "1167-1171"xsd:string |
| http://purl.uniprot.org/citations/31103264 | http://purl.uniprot.org/core/title | "Bob1 enhances RORgammat-mediated IL-17A expression in Th17 cells through interaction with RORgammat."xsd:string |
| http://purl.uniprot.org/citations/31103264 | http://purl.uniprot.org/core/volume | "514"xsd:string |
| http://purl.uniprot.org/citations/31103264 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31103264 |
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