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http://purl.uniprot.org/citations/31116781http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31116781http://www.w3.org/2000/01/rdf-schema#comment"

Background

This study aims to investigate the role of FPR 1/2/3 expressions in patients with obstructive sleep apnea (OSA).

Method

We made cross-sectional comparisons of FPR1/2/3 expressions of blood neutrophil, M1/M2a monocyte, and natural killer (NK) cell between 16 healthy subjects (HS), 16 primary snoring (PS) subjects, 46 treatment-naive OSA patients, and 18 severe OSA patients under long-term continuous positive airway pressure treatment (severe OSA on CPAP).

Results

FPR1 expressions on neutrophil were increased in treatment-naive OSA and severe OSA on CPAP groups versus either HS or PS. FPR2 expressions on neutrophil were decreased in treatment-naive OSA versus HS, and returned to normal in severe OSA on CPAP group. FPR1/FPR2 expression ratio on neutrophil was increased in treatment-naive OSA versus either HS or PS. Serum lipoxin A4, resolvin D1 levels, and FPR3 expressions of M1, M2a and NK cells were all decreased in treatment-naive OSA versus HS. OSA patients with hypertension had decreased FPR2 expressions on neutrophil and FPR3 expressions of NK cell. FPR1 expression, FPR1/FPR2 expression ratio on neutrophil, and FPR3 expression of M1 cell were all reversed after > 6-month CPAP treatment in 9 selected patients. In vitro intermittent hypoxia with re-oxygenation treatment in THP-1 cells resulted in increased FPR1/FPR2 expression ratio of M1 cells, and increased FPR1/FPR3 expression ratio of M2a cells.

Conclusions

FPR1 over-expression and insufficiency of FPR2 and FPR3 in association with defective lipoxin A4 and resolving D1 production were associated with disease severity of OSA and its adverse consequences."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0216607"xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/author"Chen Y.C."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/author"Hsu P.Y."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/author"Hsiao C.C."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/author"Lin M.C."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/author"Lin Y.Y."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/author"Wang T.Y."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/author"Zheng Y.X."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/author"Liou C.W."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/author"Huang K.T."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/author"Lin I.C."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/author"Su M.C."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/author"Chin C.H."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/name"PLoS One"xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/pages"e0216607"xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/title"Formyl peptide receptor 1 up-regulation and formyl peptide receptor 2/3 down-regulation of blood immune cells along with defective lipoxin A4/resolvin D1 production in obstructive sleep apnea patients."xsd:string
http://purl.uniprot.org/citations/31116781http://purl.uniprot.org/core/volume"14"xsd:string
http://purl.uniprot.org/citations/31116781http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31116781
http://purl.uniprot.org/citations/31116781http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31116781
http://purl.uniprot.org/uniprot/#_B2RC44-mappedCitation-31116781http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31116781
http://purl.uniprot.org/uniprot/#_P21462-mappedCitation-31116781http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31116781
http://purl.uniprot.org/uniprot/#_P25089-mappedCitation-31116781http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31116781
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