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| http://purl.uniprot.org/citations/31116987 | http://www.w3.org/2000/01/rdf-schema#comment | "Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) require the interaction of follicle-associated CXCR5+ dendritic cells with naive T cells in the draining mesenteric lymph nodes (mLNs). However, the source of CXCL13 responsible for attracting CXCR5+ dendritic cells has remained unclear. Using multiplex imaging combined with deep tissue analysis, we observed new CXCL13+ fibroblastic reticular cells surrounding paracortical and cortical B cell follicles in the mLNs of infected mice. CXCL13+ fibroblasts expressed markers of marginal reticular cells (MRCs), and their expansion required lymphotoxin (LT)-dependent interactions between IL-4Rα-expressing B cells and CCL19+ fibroblasts. Infection-induced follicles did not necessarily contain follicular dendritic cells (FDCs), indicating that CXCL13+ fibroblasts may instead drive their formation. These data reveal a role for lymphotoxin signaling to CCL19+ fibroblasts in the development of CXCL13+ MRC-like cells and adaptive type 2 immunity in response to helminth infection."xsd:string |
| http://purl.uniprot.org/citations/31116987 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.04.079"xsd:string |
| http://purl.uniprot.org/citations/31116987 | http://purl.uniprot.org/core/author | "Harris N.L."xsd:string |
| http://purl.uniprot.org/citations/31116987 | http://purl.uniprot.org/core/author | "Ludewig B."xsd:string |
| http://purl.uniprot.org/citations/31116987 | http://purl.uniprot.org/core/author | "Luther S.A."xsd:string |
| http://purl.uniprot.org/citations/31116987 | http://purl.uniprot.org/core/author | "Dubey L.K."xsd:string |
| http://purl.uniprot.org/citations/31116987 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31116987 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/31116987 | http://purl.uniprot.org/core/pages | "2442-2458.e5"xsd:string |
| http://purl.uniprot.org/citations/31116987 | http://purl.uniprot.org/core/title | "IL-4Ralpha-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells."xsd:string |
| http://purl.uniprot.org/citations/31116987 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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