| http://purl.uniprot.org/citations/31119556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31119556 | http://www.w3.org/2000/01/rdf-schema#comment | "Galectin-8 (Gal-8) is a glycan-binding protein that modulates a variety of cellular processes interacting with cell surface glycoproteins. Neutralizing anti-Gal-8 antibodies that block Gal-8 functions have been described in autoimmune and inflammatory disorders, likely playing pathogenic roles. In the brain, Gal-8 is highly expressed in the choroid plexus and accordingly has been detected in human cerebrospinal fluid. It protects against central nervous system autoimmune damage through its immune-suppressive potential. Whether Gal-8 plays a direct role upon neurons remains unknown. Here, we show that Gal-8 protects hippocampal neurons in primary culture against damaging conditions such as nutrient deprivation, glutamate-induced excitotoxicity, hydrogen peroxide (H2O2)-induced oxidative stress, and β-amyloid oligomers (Aβo). This protective action is manifested even after 2 h of exposure to the harmful condition. Pull-down assays demonstrate binding of Gal-8 to selected β1-integrins, including α3 and α5β1. Furthermore, Gal-8 activates β1-integrins, ERK1/2, and PI3K/AKT signaling pathways that mediate neuroprotection. Hippocampal neurons in primary culture produce and secrete Gal-8, and their survival decreases upon incubation with human function-blocking Gal-8 autoantibodies obtained from lupus patients. Despite the low levels of Gal-8 expression detected by real-time PCR in hippocampus, compared with other brain regions, the complete lack of Gal-8 in Gal-8 KO mice determines higher levels of apoptosis upon H2O2 stereotaxic injection in this region. Therefore, endogenous Gal-8 likely contributes to generate a neuroprotective environment in the brain, which might be eventually counteracted by human function-blocking autoantibodies."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12035-019-1621-3"xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/author | "Gonzalez A."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/author | "Inestrosa N.C."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/author | "Godoy J.A."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/author | "Metz C."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/author | "Soza A."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/author | "Retamal C."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/author | "Pardo E."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/author | "Massardo L."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/author | "Oyanadel C."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/author | "Espinoza S."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/author | "Tapia-Rojas C."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/author | "Barake F."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/name | "Mol Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/pages | "7774-7788"xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/title | "GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies."xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/31119556 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31119556 |
| http://purl.uniprot.org/citations/31119556 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31119556 |
| http://purl.uniprot.org/uniprot/#_A8DIL0-mappedCitation-31119556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31119556 |
| http://purl.uniprot.org/uniprot/#_B3F166-mappedCitation-31119556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31119556 |
| http://purl.uniprot.org/uniprot/#_B4DJG2-mappedCitation-31119556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31119556 |