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| http://purl.uniprot.org/citations/31123042 | http://www.w3.org/2000/01/rdf-schema#comment | "Alp/Enigma family members have a unique PDZ domain followed by zero to four LIM domains, and are essential for myofibril assembly across all species analyzed so far. Drosophila melanogaster has three Alp/Enigma family members, Zasp52, Zasp66, and Zasp67. Ortholog search and phylogenetic tree analysis suggest that Zasp genes have a common ancestor, and that Zasp66 and Zasp67 arose by duplication in insects. While Zasp66 has a conserved domain structure across orthologs, Zasp67 domains and lengths are highly variable. In flies, Zasp67 appears to be expressed only in indirect flight muscles, where it colocalizes with Zasp52 at Z-discs. We generated a CRISPR null mutant of Zasp67, which is viable but flightless. We can rescue all phenotypes by re-expressing a Zasp67 transgene at endogenous levels. Zasp67 mutants show extended and broken Z-discs in adult flies, indicating that the protein helps stabilize the highly regular myofibrils of indirect flight muscles. In contrast, a Zasp66 CRISPR null mutant has limited viability, but only mild indirect flight muscle defects illustrating the diverging evolutionary paths these two paralogous genes have taken since they arose by duplication."xsd:string |
| http://purl.uniprot.org/citations/31123042 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.119.302217"xsd:string |
| http://purl.uniprot.org/citations/31123042 | http://purl.uniprot.org/core/author | "Katzemich A."xsd:string |
| http://purl.uniprot.org/citations/31123042 | http://purl.uniprot.org/core/author | "Gonzalez-Morales N."xsd:string |
| http://purl.uniprot.org/citations/31123042 | http://purl.uniprot.org/core/author | "Schock F."xsd:string |
| http://purl.uniprot.org/citations/31123042 | http://purl.uniprot.org/core/author | "Xiao Y.S."xsd:string |
| http://purl.uniprot.org/citations/31123042 | http://purl.uniprot.org/core/author | "Marescal O."xsd:string |
| http://purl.uniprot.org/citations/31123042 | http://purl.uniprot.org/core/author | "Marsh T.W."xsd:string |
| http://purl.uniprot.org/citations/31123042 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31123042 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/31123042 | http://purl.uniprot.org/core/pages | "743-755"xsd:string |
| http://purl.uniprot.org/citations/31123042 | http://purl.uniprot.org/core/title | "Different Evolutionary Trajectories of Two Insect-Specific Paralogous Proteins Involved in Stabilizing Muscle Myofibrils."xsd:string |
| http://purl.uniprot.org/citations/31123042 | http://purl.uniprot.org/core/volume | "212"xsd:string |
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