| http://purl.uniprot.org/citations/31123064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31123064 | http://www.w3.org/2000/01/rdf-schema#comment | "Coordinated induction, but also repression, of genes are key to normal differentiation. Although the role of lineage-specific transcription regulators has been studied extensively, their functional integration with chromatin remodelers, one of the key enzymatic machineries that control chromatin accessibility, remains ill-defined. Here we investigate the role of Mi-2β, a SNF-2-like nucleosome remodeler and key component of the nucleosome remodeling and histone deacetylase (NuRD) complex in early B cells. Inactivation of Mi-2β arrested differentiation at the large pre-B-cell stage and caused derepression of cell adhesion and cell migration signaling factors by increasing chromatin access at poised enhancers and chromosome architectural elements. Mi-2β also supported IL-7R signaling, survival, and proliferation by repressing negative effectors of this pathway. Importantly, overexpression of Bcl2, a mitochondrial prosurvival gene and target of IL-7R signaling, partly rescued the differentiation block caused by Mi-2β loss. Mi-2β stably associated with chromatin sites that harbor binding motifs for IKAROS and EBF1 and physically associated with these transcription factors both on and off chromatin. Notably, Mi-2β shared loss-of-function cellular and molecular phenotypes with IKAROS and EBF1, albeit in a distinct fashion. Thus, the nucleosome remodeler Mi-2β promotes pre-B-cell differentiation by providing repression capabilities to distinct lineage-specific transcription factor-based regulatory networks."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.321901.118"xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/author | "Yoshida T."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/author | "Williams C.J."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/author | "Galani K."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/author | "Georgopoulos K."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/author | "Gounari F."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/author | "Tolstorukov M.Y."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/author | "Snippert H.J."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/author | "Muhire B."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/author | "Emmanuel A.O."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/pages | "763-781"xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/title | "Chromatin restriction by the nucleosome remodeler Mi-2beta and functional interplay with lineage-specific transcription regulators control B-cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/31123064 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31123064 |
| http://purl.uniprot.org/citations/31123064 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31123064 |
| http://purl.uniprot.org/uniprot/#_E9QAS4-mappedCitation-31123064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31123064 |
| http://purl.uniprot.org/uniprot/#_E9QAS5-mappedCitation-31123064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31123064 |
| http://purl.uniprot.org/uniprot/#_F6WR45-mappedCitation-31123064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31123064 |
| http://purl.uniprot.org/uniprot/#_G5E8V7-mappedCitation-31123064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31123064 |