| http://purl.uniprot.org/citations/31130486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31130486 | http://www.w3.org/2000/01/rdf-schema#comment | "MsbA is an essential ATP-binding cassette transporter in Gram-negative bacteria that transports lipid A and lipopolysaccharide from the cytoplasmic leaflet to the periplasmic leaflet of the inner membrane. Here we report the X-ray structure of MsbA from Salmonella typhimurium at 2.8-Å resolution in an inward-facing conformation after cocrystallization with lipid A and using a stabilizing facial amphiphile. The structure displays a large amplitude opening in the transmembrane portal, which is likely required for lipid A to pass from its site of synthesis into the protein-enclosed transport pathway. Putative lipid A density is observed further inside the transmembrane cavity, consistent with a trap and flip model. Additional electron density attributed to lipid A is observed near an outer surface cleft at the periplasmic ends of the transmembrane helices. These findings provide new structural insights into the lipid A transport pathway through comparative analysis with existing MsbA structures."xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2019.04.007"xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://purl.uniprot.org/core/author | "Lee S.C."xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://purl.uniprot.org/core/author | "Stanfield R.L."xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://purl.uniprot.org/core/author | "Tajkhorshid E."xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://purl.uniprot.org/core/author | "Padayatti P.S."xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://purl.uniprot.org/core/author | "Wen P.C."xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31130486 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://purl.uniprot.org/core/pages | "1114-1123.e3"xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://purl.uniprot.org/core/title | "Structural Insights into the Lipid A Transport Pathway in MsbA."xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/31130486 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31130486 |
| http://purl.uniprot.org/citations/31130486 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31130486 |
| http://purl.uniprot.org/uniprot/#_P63359-mappedCitation-31130486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31130486 |
| http://purl.uniprot.org/uniprot/P63359 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31130486 |