| http://purl.uniprot.org/citations/31135379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31135379 | http://www.w3.org/2000/01/rdf-schema#comment | "Idiopathic Pulmonary Fibrosis (IPF) is a deadly disease with limited therapies. Tissue fibrosis is associated with Type 2 immune response, although the causal contribution of immune cells is not defined. The AP-1 transcription factor Fra-2 is upregulated in IPF lung sections and Fra-2 transgenic mice (Fra-2tg) exhibit spontaneous lung fibrosis. Here we show that Bleomycin-induced lung fibrosis is attenuated upon myeloid-inactivation of Fra-2 and aggravated in Fra-2tg bone marrow chimeras. Type VI collagen (ColVI), a Fra-2 transcriptional target, is up-regulated in three lung fibrosis models, and macrophages promote myofibroblast activation in vitro in a ColVI- and Fra-2-dependent manner. Fra-2 or ColVI inactivation does not affect macrophage recruitment and alternative activation, suggesting that Fra-2/ColVI specifically controls the paracrine pro-fibrotic activity of macrophages. Importantly, ColVI knock-out mice (KO) and ColVI-KO bone marrow chimeras are protected from Bleomycin-induced lung fibrosis. Therapeutic administration of a Fra-2/AP-1 inhibitor reduces ColVI expression and ameliorates fibrosis in Fra-2tg mice and in the Bleomycin model. Finally, Fra-2 and ColVI positively correlate in IPF patient samples and co-localize in lung macrophages. Therefore, the Fra-2/ColVI pro-fibrotic axis is a promising biomarker and therapeutic target for lung fibrosis, and possibly other fibrotic diseases."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci125366"xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Wagner E.F."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Jimenez M."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Mandal P."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Bonaldo P."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Braghetta P."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Ximenez-Embun P."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Megias D."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Bakiri L."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Roediger B."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Hernandez A.I."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Paz-Ares L."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Ucero A.C."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/author | "Fustero-Torre C."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/pages | "3293-3309"xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/title | "Fra-2-expressing macrophages promote lung fibrosis in mice."xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/31135379 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31135379 |
| http://purl.uniprot.org/citations/31135379 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31135379 |
| http://purl.uniprot.org/uniprot/P47930#attribution-0C4F14BA3F07781C639981FB01824F2C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31135379 |