| http://purl.uniprot.org/citations/31136580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31136580 | http://www.w3.org/2000/01/rdf-schema#comment | "Petite Integration Factor 1 (PIF1) is a multifunctional helicase present in nuclei and mitochondria. PIF1 knock out (KO) mice exhibit accelerated weight gain and decreased wheel running on a normal chow diet. In the current study, we investigated whether Pif1 ablation alters whole body metabolism in response to weight gain. PIF1 KO and wild type (WT) C57BL/6J mice were fed a Western diet (WD) rich in fat and carbohydrates before evaluation of their metabolic phenotype. Compared with weight gain-resistant WT female mice, WD-fed PIF1 KO females, but not males, showed accelerated adipose deposition, decreased locomotor activity, and reduced whole-body energy expenditure without increased dietary intake. Surprisingly, PIF1 KO females did not show obesity-induced alterations in fasting blood glucose and glucose clearance. WD-fed PIF1 KO females developed mild hepatic steatosis and associated changes in liver gene expression that were absent in weight-matched, WD-fed female controls, linking hepatic steatosis to Pif1 ablation rather than increased body weight. WD-fed PIF1 KO females also showed decreased expression of inflammation-associated genes in adipose tissue. Collectively, these data separated weight gain from inflammation and impaired glucose homeostasis. They also support a role for Pif1 in weight gain resistance and liver metabolic dysregulation during nutrient stress."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0203101"xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Chu Y."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Kaufman B.A."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Harrington L."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Jurczak M.J."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Shiva S."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Bannwarth S."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Paquis-Flucklinger V."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "O'Doherty R.M."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Dedousis N."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Singhi A.D."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Sipula I."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Belmonte F.R."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/author | "Desai N.A."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/pages | "e0203101"xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/title | "Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance."xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/31136580 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31136580 |
| http://purl.uniprot.org/citations/31136580 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31136580 |
| http://purl.uniprot.org/uniprot/#_D3YZ87-mappedCitation-31136580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31136580 |