| http://purl.uniprot.org/citations/31138843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31138843 | http://www.w3.org/2000/01/rdf-schema#comment | "A large body of evidence suggests that B-cell lymphomas with enhanced Myc expression are associated with an aggressive phenotype and poor prognosis, which makes Myc a compelling therapeutic target. Phosphodiesterase 4B (PDE4B), a main hydrolyzer of cyclic AMP (cAMP) in B cells, was shown to be involved in cell survival and drug resistance in diffuse large B cell lymphomas (DLBCL). However, the interrelationship between Myc and PDE4B remains unclear. Here, we first demonstrate the presence of the Myc-PDE4B feed-forward loop, in which Myc and PDE4B mutually reinforce the expression of each other. Next, the combined targeting of Myc and PDE4 synergistically prevented the proliferation and survival of B lymphoma cells in vitro and in a mouse xenograft model. We finally recapitulated this combinatorial effect in Eμ-myc transgenic mice; co-inhibition of Myc and PDE4 suppressed lymphomagenesis and restored B cell development to the wild type level that was associated with marked reduction in Myc levels, unveiling the critical role of the Myc-PDE4B amplification loop in the regulation of Myc expression and the pathogenesis of B cell lymphoma. These findings suggest that the disruption of the Myc-PDE4B circuitry can be exploited in the treatment of B cell malignancies."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41375-019-0492-y"xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Kim Y.W."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Kim A."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Nam J."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Sun H."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Kim S.W."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Lee Y.H."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Shin H.J."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Kim D.U."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Park B.J."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Park I."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Jung Y."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Jeong J.Y."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Ko M.J."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Kwak B."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Song D.K."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/author | "Oh A.Y."xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/pages | "2912-2923"xsd:string |
| http://purl.uniprot.org/citations/31138843 | http://purl.uniprot.org/core/title | "Disruption of the Myc-PDE4B regulatory circuitry impairs B-cell lymphoma survival."xsd:string |