| http://purl.uniprot.org/citations/31139177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31139177 | http://www.w3.org/2000/01/rdf-schema#comment | "Thymic stromal lymphopoietin (TSLP) is a functionally pleotropic cytokine important in immune regulation, and TSLP dysregulation is associated with numerous diseases. TSLP is produced by many cell types, but has predominantly been characterized as a secreted factor from epithelial cells which activates dendritic cells (DC) that subsequently prime T helper (TH) 2 immunity. However, DC themselves make significant amounts of TSLP in response to microbial products, but the functional role of DC-derived TSLP remains unclear. We show that TSLPR signaling negatively regulates IL-1β production during dectin-1 stimulation of human DC. This regulatory mechanism functions by dampening Syk phosphorylation and is mediated via NADPH oxidase-derived ROS, HIF-1α and pro-IL-1β expression. Considering the profound effect TSLPR signaling has on the metabolic status and the secretome of dectin-1 stimulated DC, these data suggest that autocrine TSLPR signaling could have a fundamental role in modulating immunological effector responses at sites removed from epithelial cell production of TSLP."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2019.00921"xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/author | "Williams D.L."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/author | "Steinmetz M."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/author | "Goodall J.C."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/author | "Gaston J.S.H."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/author | "Cohen E.S."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/author | "Mallat Z."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/author | "Chee R."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/author | "Fitzmaurice T.J."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/author | "Webster S.J."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/author | "Elder M.J."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/author | "Shaunak A.S.D."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/pages | "921"xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/title | "Dendritic Cell-Derived TSLP Negatively Regulates HIF-1alpha and IL-1beta During Dectin-1 Signaling."xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31139177 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31139177 |
| http://purl.uniprot.org/citations/31139177 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31139177 |
| http://purl.uniprot.org/uniprot/#_D0VY79-mappedCitation-31139177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31139177 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG43-mappedCitation-31139177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31139177 |
| http://purl.uniprot.org/uniprot/#_A0A510GAG5-mappedCitation-31139177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31139177 |
| http://purl.uniprot.org/uniprot/#_B2R617-mappedCitation-31139177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31139177 |