| http://purl.uniprot.org/citations/31160417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31160417 | http://www.w3.org/2000/01/rdf-schema#comment | "The Cre/loxP system has been used extensively in mouse models with a limitation of one lineage at a time. Differences in function and other properties among populations of adult β-cells is termed β-cell heterogeneity, which was recently associated with diabetic phenotypes. Nevertheless, the presence of a developmentally derived β-cell heterogeneity is unclear. Here, we have developed a novel dual lineage-tracing technology, using a combination of two recombinase systems, Dre/RoxP and Cre/LoxP, to independently trace green fluorescent Pdx1-lineage cells and red fluorescent Ptf1a-lineage cells in the developing and adult mouse pancreas. We detected a few Pdx1+/Ptf1a- lineage cells in addition to the vast majority of Pdx1+/Ptf1a+ lineage cells in the pancreas. Moreover, Pdx1+/Ptf1a+ lineage β-cells had fewer Ki-67+ proliferating β-cells, and expressed higher mRNA levels of insulin, Glut2, Pdx1, MafA and Nkx6.1, but lower CCND1 and CDK4 levels, compared with Pdx1+/Ptf1a- lineage β-cells. Furthermore, more TSQ-high, SSC-high cells were detected in the Pdx1+Ptf1a+ lineage population than in the Pdx1+Ptf1a- lineage population. Together, these data suggest that differential activation of Ptf1a in the developing pancreas may correlate with this β-cell heterogeneity."xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.164913"xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/author | "Xiao X."xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/author | "Shiota C."xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/author | "Prasadan K."xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/author | "Gittes G.K."xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/author | "Agostinelli G."xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/author | "Ridley D."xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/pages | "dev164913"xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/title | "Evidence of a developmental origin for beta-cell heterogeneity using a dual lineage-tracing technology."xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://purl.uniprot.org/core/volume | "146"xsd:string |
| http://purl.uniprot.org/citations/31160417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31160417 |
| http://purl.uniprot.org/citations/31160417 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31160417 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-31160417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31160417 |
| http://purl.uniprot.org/uniprot/#_D3Z595-mappedCitation-31160417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31160417 |
| http://purl.uniprot.org/uniprot/#_D3Z596-mappedCitation-31160417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31160417 |
| http://purl.uniprot.org/uniprot/#_E0CXX7-mappedCitation-31160417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31160417 |
| http://purl.uniprot.org/uniprot/#_D3YWU5-mappedCitation-31160417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31160417 |
| http://purl.uniprot.org/uniprot/#_P52946-mappedCitation-31160417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31160417 |