| http://purl.uniprot.org/citations/31160551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31160551 | http://www.w3.org/2000/01/rdf-schema#comment | "Intersectin1 (ITSN1) contains two isoforms: ITSN1-S and ITSN1-L, which is highly regulated by alternative splicing. However, the alteration of alternative splicing and its importance in cancer is still unknown. In this study, our transcriptome analysis by using a large glioma cohort indicated the two isoforms exerted opposite function in glioma progression. Our previous results had shown ITSN1-S could promote glioma development; however, the function of ITSN1-L remained unknown. In this study, we first confirmed that ITSN1-L exerted an inhibitory role in glioma progression both in vivo and in vitro, which was contrary to the function of ITSN1-S. In additional, we also elucidated the mechanisms of ITSN1-L in inhibiting tumor progression. First, we revealed ITSN1-L could interact with α-tubulin to promote HDAC6-dependent deacetylation of ac-tubulin leading to decreased cell motility. Second, ITSN1-L could attenuate cell-substrate adhesion through FAK/integrin β3 pathway. Third, ITSN1-L was able to strengthen cell-cell adhesion by upregulating N-cadherin expression and its re-localization to membrane by ANXA2 and TUBB3/TUBB4. In conclusion, we found for the first time that two isoforms produced by alternative splicing exerted opposite functions in glioma development. Therefore, upregulation of ITSN1-L expression as well as downregulation of ITSN1-S expression probably was a better strategy in glioma treatment. Our present study laid a foundation for the importance of alternative splicing in glioma progression and raised the possibility of controlling glioma development completely at an alternative splicing level to be a more effective strategy."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-019-1668-0"xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/author | "Guo Z."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/author | "Xu Q."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/author | "Shao Y."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/author | "Gu F."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/author | "Chong W."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/pages | "431"xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/title | "Alternative splicing-derived intersectin1-L and intersectin1-S exert opposite function in glioma progression."xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31160551 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31160551 |
| http://purl.uniprot.org/citations/31160551 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31160551 |
| http://purl.uniprot.org/uniprot/#_A7XZY7-mappedCitation-31160551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31160551 |
| http://purl.uniprot.org/uniprot/#_A0A2X0TVY8-mappedCitation-31160551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31160551 |
| http://purl.uniprot.org/uniprot/#_A8CTZ0-mappedCitation-31160551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31160551 |
| http://purl.uniprot.org/uniprot/#_A8W608-mappedCitation-31160551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31160551 |