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http://purl.uniprot.org/citations/31163432http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31163432http://www.w3.org/2000/01/rdf-schema#comment"

Background/aims

Growth differentiation factor-15 (GDF-15) expression has been reported to increase in response to tissue damage and has recently emerged as a useful biomarker for various diseases. Although emerging evidence supports the clinicopathological value of GDF-15 in renal impairment, few studies have analyzed it in the elderly. Thus, we conducted a cross-sectional study to investigate the association of plasma GDF-15 with renal function and the presence of chronic kidney disease (CKD) in community-dwelling elderly.

Materials

The present study was based on the baseline data of the Korean Frailty and Aging Cohort Study (KFACS), a nationwide cohort study that began in 2016. Of the 1,559 participants assessed in the first year, 443 with available plasma GDF-15 data were enrolled in this study. We investigated the association of plasma GDF-15 levels with clinical and biochemical parameters. The study population was divided into two groups according to renal function (CKD and non-CKD groups) to investigate whether GDF-15 can determine the presence of renal dysfunction in the elderly. Plasma GDF-15 was measured by enzyme-linked immunosorbent assay (ELISA) kit.

Results

In a simple regression analysis, the levels of plasma GDF-15 were negatively correlated with estimated glomerular filtration rate (eGFR; r = -0.383, p < 0.001). In multiple linear regression analysis, GDF-15 levels were still significantly correlated with eGFR, even after adjusting for other parameters (r = -0.259, p < 0.001). Plasma GDF-15 levels were significantly higher in the elderly with CKD than in those without CKD (2,364.025 ± 1,052.23 ng/L and 1,451.23 ± 835.79 ng/L, respectively; p < 0.001). The optimal cut-off value of plasma GDF-15 for detecting the presence of CKD was 1,699.4 ng/L (76.5% sensitivity and 76.0% specificity), as determined by the receiver operating characteristic curve. The area under the curve was 0.793 ± 0.033 (95% CI 0.729-0.857, p < 0.001).

Conclusion

Plasma GDF-15 levels were negatively associated with eGFR and were significantly increased in the elderly with CKD. Our results suggested that plasma GDF-15 might be a useful marker for discriminating renal impairment in the elderly. Further large and prospective outcome studies of extended duration are needed."xsd:string
http://purl.uniprot.org/citations/31163432http://purl.org/dc/terms/identifier"doi:10.1159/000498959"xsd:string
http://purl.uniprot.org/citations/31163432http://purl.uniprot.org/core/author"Kim J.S."xsd:string
http://purl.uniprot.org/citations/31163432http://purl.uniprot.org/core/author"Kim S."xsd:string
http://purl.uniprot.org/citations/31163432http://purl.uniprot.org/core/author"Jeong K.H."xsd:string
http://purl.uniprot.org/citations/31163432http://purl.uniprot.org/core/author"Won C.W."xsd:string
http://purl.uniprot.org/citations/31163432http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31163432http://purl.uniprot.org/core/name"Kidney Blood Press Res"xsd:string
http://purl.uniprot.org/citations/31163432http://purl.uniprot.org/core/pages"405-414"xsd:string
http://purl.uniprot.org/citations/31163432http://purl.uniprot.org/core/title"Association between Plasma Levels of Growth Differentiation Factor-15 and Renal Function in the Elderly: Korean Frailty and Aging Cohort Study."xsd:string
http://purl.uniprot.org/citations/31163432http://purl.uniprot.org/core/volume"44"xsd:string
http://purl.uniprot.org/citations/31163432http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31163432
http://purl.uniprot.org/citations/31163432http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31163432
http://purl.uniprot.org/uniprot/#_Q99988-mappedCitation-31163432http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31163432
http://purl.uniprot.org/uniprot/Q99988http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/31163432