| http://purl.uniprot.org/citations/31166618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31166618 | http://www.w3.org/2000/01/rdf-schema#comment | "The intestinal microbiota has several effects on host physiology. Previous work from our laboratory demonstrated that the microbiota influences systemic iron homeostasis in mouse colitis models by altering inflammation-induced expression of the iron-regulating hormone hepcidin. In the present study, we examined the impact of the gut commensal bacterium Bacteroides fragilis on the expression of the iron exporter ferroportin, the target of hepcidin action, in macrophages, the cell type that plays a pivotal role in iron recycling. Mouse bone marrow-derived macrophages were exposed to B. fragilis and were analyzed by quantitative real-time polymerase chain reaction and Western blotting. We found that B. fragilis down-regulated ferroportin transcription independently of bacterial viability. Medium conditioned by the bacteria also reduced ferroportin expression, indicating the involvement of soluble factors, possibly Toll-like receptor ligands. Consistent with this idea, several of these ligands were able to down-regulate ferroportin. The B. fragilis-induced decrease in ferroportin was functionally important since it produced a significant increase in intracellular iron concentrations that prevented the effects of the iron chelator deferoxamine on Salmonella-induced IL-6 and IL-1β production. Our results thus reveal that B. fragilis can influence macrophage iron handling and inflammatory responses by modulating ferroportin expression."xsd:string |
| http://purl.uniprot.org/citations/31166618 | http://purl.org/dc/terms/identifier | "doi:10.1002/jlb.2a1018-408rr"xsd:string |
| http://purl.uniprot.org/citations/31166618 | http://purl.uniprot.org/core/author | "Cherayil B.J."xsd:string |
| http://purl.uniprot.org/citations/31166618 | http://purl.uniprot.org/core/author | "Verma S."xsd:string |
| http://purl.uniprot.org/citations/31166618 | http://purl.uniprot.org/core/author | "Prescott R."xsd:string |
| http://purl.uniprot.org/citations/31166618 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31166618 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/31166618 | http://purl.uniprot.org/core/pages | "1079-1088"xsd:string |
| http://purl.uniprot.org/citations/31166618 | http://purl.uniprot.org/core/title | "The commensal bacterium Bacteroides fragilis down-regulates ferroportin expression and alters iron homeostasis in macrophages."xsd:string |
| http://purl.uniprot.org/citations/31166618 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/31166618 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31166618 |
| http://purl.uniprot.org/citations/31166618 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31166618 |
| http://purl.uniprot.org/uniprot/#_C5H8V4-mappedCitation-31166618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31166618 |
| http://purl.uniprot.org/uniprot/#_Q3TJ33-mappedCitation-31166618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31166618 |
| http://purl.uniprot.org/uniprot/#_Q9JHI9-mappedCitation-31166618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31166618 |
| http://purl.uniprot.org/uniprot/Q9JHI9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31166618 |
| http://purl.uniprot.org/uniprot/C5H8V4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31166618 |
| http://purl.uniprot.org/uniprot/Q3TJ33 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31166618 |