| http://purl.uniprot.org/citations/31167132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31167132 | http://www.w3.org/2000/01/rdf-schema#comment | "To reveal the relative contribution of the recombination activating gene (RAG)1/2 nuclease to lymphomagenesis, we conducted a genome-wide analysis of T cell lymphomas from p53-deficient mice expressing or lacking RAG2. We found that while p53-/- lymphoblastic T cells harbor primarily ectopic DNA deletions, Rag2-/-p53-/- T cell lymphomas display complex genomic rearrangements associated with amplification of the chromosomal location 9qA4-5.3. We show that this amplicon is generated by breakage-fusion-bridge during mitosis and arises distinctly in T cell lymphomas originating from an early progenitor stage. Notably, we report amplification of the corresponding syntenic region (11q23) in a subset of human leukemia leading to the overexpression of several cancer genes, including MLL/KMT2A. Our findings provide direct evidence that lymphocytes undergo malignant transformation through distinct genome architectural routes that are determined by both RAG-dependent and RAG-independent DNA damage and a block in cell development."xsd:string |
| http://purl.uniprot.org/citations/31167132 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.05.014"xsd:string |
| http://purl.uniprot.org/citations/31167132 | http://purl.uniprot.org/core/author | "Bianchi J.J."xsd:string |
| http://purl.uniprot.org/citations/31167132 | http://purl.uniprot.org/core/author | "Deriano L."xsd:string |
| http://purl.uniprot.org/citations/31167132 | http://purl.uniprot.org/core/author | "Lescale C."xsd:string |
| http://purl.uniprot.org/citations/31167132 | http://purl.uniprot.org/core/author | "Bedora-Faure M."xsd:string |
| http://purl.uniprot.org/citations/31167132 | http://purl.uniprot.org/core/author | "Murigneux V."xsd:string |
| http://purl.uniprot.org/citations/31167132 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31167132 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/31167132 | http://purl.uniprot.org/core/pages | "2847-2858.e4"xsd:string |
| http://purl.uniprot.org/citations/31167132 | http://purl.uniprot.org/core/title | "Breakage-Fusion-Bridge Events Trigger Complex Genome Rearrangements and Amplifications in Developmentally Arrested T Cell Lymphomas."xsd:string |
| http://purl.uniprot.org/citations/31167132 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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