| http://purl.uniprot.org/citations/31167387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31167387 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute myeloid leukaemia (AML) is a heterogeneous clonal malignancy of hematopoietic progenitor cells. The Wnt pathway and its downstream targets are tightly regulated by β-catenin. We recently discovered a new protein, FLYWCH1, which can directly bind nuclear β-catenin. Herein, we studied the FLYWCH1/β-catenin pathway in AML cells using qRT-PCR, Western blot, and immunofluorescence assays. In addition, the stemness activity and cell cycle were analysed by the colony-forming unit (CFU) using methylcellulose-based and Propidium iodide/flow cytometry assays. We found that FLYWCH1 mRNA and protein were differentially expressed in the AML cell lines. C-Myc, cyclin D1, and c-Jun expression decreased in the presence of higher FLYWCH1 expression, and vice versa. There appeared to be the loss of FLYWCH1 expression in dividing cells. The sub-G0 phase was prolonged and shortened in the low and high FLYWCH1 expression cell lines, respectively. The G0/G1 arrest correlated with FLYWCH1-expression, and these cell lines also formed colonies, whereas the low FLYWCH1 expression cell lines could not. Thus, FLYWCH1 functions as a negative regulator of the Wnt/β-catenin pathway in AML."xsd:string |
| http://purl.uniprot.org/citations/31167387 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms20112739"xsd:string |
| http://purl.uniprot.org/citations/31167387 | http://purl.uniprot.org/core/author | "Almozyan S."xsd:string |
| http://purl.uniprot.org/citations/31167387 | http://purl.uniprot.org/core/author | "Babaei-Jadidi R."xsd:string |
| http://purl.uniprot.org/citations/31167387 | http://purl.uniprot.org/core/author | "Nateri A.S."xsd:string |
| http://purl.uniprot.org/citations/31167387 | http://purl.uniprot.org/core/author | "Onyido E.K."xsd:string |
| http://purl.uniprot.org/citations/31167387 | http://purl.uniprot.org/core/author | "Seedhouse C."xsd:string |
| http://purl.uniprot.org/citations/31167387 | http://purl.uniprot.org/core/author | "Chondrou P.S."xsd:string |
| http://purl.uniprot.org/citations/31167387 | http://purl.uniprot.org/core/author | "Almars A."xsd:string |
| http://purl.uniprot.org/citations/31167387 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31167387 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/31167387 | http://purl.uniprot.org/core/pages | "E2739"xsd:string |
| http://purl.uniprot.org/citations/31167387 | http://purl.uniprot.org/core/title | "Increased FLYWCH1 Expression is Negatively Correlated with Wnt/beta-catenin Target Gene Expression in Acute Myeloid Leukemia Cells."xsd:string |
| http://purl.uniprot.org/citations/31167387 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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