| http://purl.uniprot.org/citations/31175056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31175056 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundPre-eclampsia is a leading cause of maternal mortality and morbidity. Although the exact mechanisms that cause pre-eclampsia remain unclear, it is undeniable that abnormal placental function and circulation are a center for initiation pre-eclampsia. As a potent vasoconstrictor, arginine vasopressin (AVP) has long been implicated in controlling placental vascular tone and circulation; its secretion is grossly elevated in pre-eclamptic circulation. However, little is known about the reactivity of AVP in pre-eclamptic placental vasculature.MethodsTo reveal the special features of placental vascular regulations with placental pathophysiological changes, as well as the corresponding molecular mechanisms under pre-eclamptic conditions, vascular function and molecular assays were conducted with placental vessel samples from normal and pre-eclamptic pregnancies.FindingsThe present study found that vasoconstriction responses of placental vessels to AVP were attenuated in pre-eclampsia as compared to in normal pregnancy. The insensitivity of AVP was correlated with the down-regulated AVP receptor 1a (AVPR1A, AVPR1A gene) and protein kinase C isoform β (PKCβ, PKCΒ gene), particularly the hyper-methylation-mediated AVPR1A and PKCΒ gene down-regulation, respectively.InterpretationThe findings collectively revealed that aberrant DNA methylation-mediated gene expressions are correlated with vascular dysfunction in pre-eclamptic placental circulation. FUND: This work was supported by National Nature & Science Foundation of China. "333 Project", "Six one project", "Shuang Chuang Tuan Dui" and Key Discipline "Fetal medicine" of Jiangsu Province, and the Suzhou city "Wei Sheng Ren Cai" program."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ebiom.2019.05.056"xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/author | "Fan X."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/author | "Tao J."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/author | "Xu T."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/author | "Ding H."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/author | "Gao Q."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/name | "EBioMedicine"xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/pages | "574-581"xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/title | "Hyper-methylation of AVPR1A and PKCBeta gene associated with insensitivity to arginine vasopressin in human pre-eclamptic placental vasculature."xsd:string |
| http://purl.uniprot.org/citations/31175056 | http://purl.uniprot.org/core/volume | "44"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q9UH72-mappedCitation-31175056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31175056 |