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http://purl.uniprot.org/citations/31175361http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31175361http://www.w3.org/2000/01/rdf-schema#comment"Mycobacterium ensures its survival inside macrophages and long-term infection by subverting the innate and adaptive immune response through the modulation of cytokine gene expression profiles. Different Mycobacterium species promote the expression of TGFβ and IL-10, which, at the early stages of infection, block the formation of the phagolysosome, thereby securing mycobacterial survival upon phagocytosis, and at later stages, antagonize IFNγ production and functions. Despite the key role of IL-10 in mycobacterium infection, the signal transduction pathways leading to IL-10 expression in infected macrophages are poorly understood. Here, we report that Mycobacterium bovis BCG promotes IL-10 expression and cytokine production by establishing a SYK/PKCα/β positive feedback loop that leads to STAT3 activation."xsd:string
http://purl.uniprot.org/citations/31175361http://purl.org/dc/terms/identifier"doi:10.1093/femspd/ftz032"xsd:string
http://purl.uniprot.org/citations/31175361http://purl.uniprot.org/core/author"Pedraza-Alva G."xsd:string
http://purl.uniprot.org/citations/31175361http://purl.uniprot.org/core/author"Perez-Martinez L."xsd:string
http://purl.uniprot.org/citations/31175361http://purl.uniprot.org/core/author"Madrid-Paulino E."xsd:string
http://purl.uniprot.org/citations/31175361http://purl.uniprot.org/core/author"Maldonado-Bravo R."xsd:string
http://purl.uniprot.org/citations/31175361http://purl.uniprot.org/core/author"Villasenor T."xsd:string
http://purl.uniprot.org/citations/31175361http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31175361http://purl.uniprot.org/core/name"Pathog Dis"xsd:string
http://purl.uniprot.org/citations/31175361http://purl.uniprot.org/core/pages"ftz032"xsd:string
http://purl.uniprot.org/citations/31175361http://purl.uniprot.org/core/title"Mycobacterium bovis BCG promotes IL-10 expression by establishing a SYK/PKCalpha/beta positive autoregulatory loop that sustains STAT3 activation."xsd:string
http://purl.uniprot.org/citations/31175361http://purl.uniprot.org/core/volume"77"xsd:string
http://purl.uniprot.org/citations/31175361http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31175361
http://purl.uniprot.org/citations/31175361http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31175361
http://purl.uniprot.org/uniprot/#_B7ZA24-mappedCitation-31175361http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31175361
http://purl.uniprot.org/uniprot/#_A0A7I2V395-mappedCitation-31175361http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31175361
http://purl.uniprot.org/uniprot/#_A8K4G2-mappedCitation-31175361http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31175361
http://purl.uniprot.org/uniprot/#_B3KQJ1-mappedCitation-31175361http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31175361
http://purl.uniprot.org/uniprot/#_B3VI66-mappedCitation-31175361http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31175361
http://purl.uniprot.org/uniprot/#_B4DNP0-mappedCitation-31175361http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31175361
http://purl.uniprot.org/uniprot/#_B4DVR6-mappedCitation-31175361http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31175361
http://purl.uniprot.org/uniprot/#_C3W980-mappedCitation-31175361http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31175361
http://purl.uniprot.org/uniprot/#_C3W981-mappedCitation-31175361http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31175361
http://purl.uniprot.org/uniprot/#_B5BTZ6-mappedCitation-31175361http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31175361