Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/31177127http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31177127http://www.w3.org/2000/01/rdf-schema#comment"

Background/aim

Long-term exposure to betel quid (BQ)-, cigarette-, and alcohol-induced chronic inflammation is a crucial risk factor for oral and pharyngeal squamous cell carcinoma (OPSCC) progression. We analyzed the genotypes of stromal-cell-derived factor-1 (SDF-1) and CXC-chemokine receptor-4 (CXCR4) and determined the association between their polymorphisms and the risk of OPSCC.

Materials and methods

This study consisted of 452 patients with pathologically proved OPSCC and 424 sex- and age-matched cancer-free controls. The genotypes of SDF-1 and CXCR4 were detected through the TaqMan real-time polymerase chain reaction (PCR) method.

Results

Our data indicated that the C allele and C/C genotypes of CXCR4 were significantly associated with OPSCC [adjusted odds ratio (AOR)=1.41, 95% confidence interval (CI):1.02-1.96, p=0.037 and AOR=1.51, 95% CI:1.05-2.17, p=0.028, respectively] and OSCC (AOR=1.41, 95%CI:1.00-2.00, p=0.049 and AOR=1.49, 95%CI:1.01-2.20, p=0.044, respectively) risk. Patients with genetic polymorphisms of the genotype combination SDF-1/CXCR4 had a higher risk of OSCC (p trend=0.033). We analyzed the effects of CXCR4 genetic variants on susceptibility to OPSCC in patients with different risk habits of BQ chewing, tobacco smoking and alcohol consumption, and revealed that C/T+T/T genotypes exerted an increased risk only in patients with one (AOR=2.68, p=0.036) or two risk habits (AOR=2.02, p=0.027) compared to patients with the C/C genotype.

Conclusion

We concluded that CXCR4 C>T can be used as a genetic marker of susceptibility to OPSCC, particularly in OPSCC patients with one or two types of risk habits with a synergistic effect."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.org/dc/terms/identifier"doi:10.21873/anticanres.13418"xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Lee J.H."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Lin Y.C."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Wang C.C."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Wu P.C."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Lin M.H."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Lo Y.H."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Yang C.M."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Huang S.J."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Tseng Y.K."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Liang C.C."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Liou H.H."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Tsai K.W."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Ger L.P."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/author"Yen L.M."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/name"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/pages"2891-2902"xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/title"Association of SDF-1 and CXCR4 Polymorphisms With Susceptibility to Oral and Pharyngeal Squamous Cell Carcinoma."xsd:string
http://purl.uniprot.org/citations/31177127http://purl.uniprot.org/core/volume"39"xsd:string
http://purl.uniprot.org/citations/31177127http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31177127
http://purl.uniprot.org/citations/31177127http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31177127
http://purl.uniprot.org/uniprot/#_A0A0U3FJG0-mappedCitation-31177127http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31177127
▶