| http://purl.uniprot.org/citations/31178353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31178353 | http://www.w3.org/2000/01/rdf-schema#comment | "Many microRNAs (miRNAs) exist alongside abundant miRNA isoforms (isomiRs), most of which arise from post-maturation sequence modifications such as 3' uridylation. However, the ways in which these sequence modifications affect miRNA function remain poorly understood. Here, using human miR-27a in cell lines as a model, we discovered that a nonfunctional target site unable to base-pair extensively with the miRNA seed sequence can regain function when an upstream adenosine is able to base-pair with a post-transcriptionally added uridine in the miR-27a tail. This tail-U-mediated repression (TUMR) is abolished in cells lacking the uridylation enzymes TUT4 and TUT7, indicating that uridylation alters miRNA function by modulating target recognition. We identified a set of non-canonical targets in human cells that are specifically regulated by uridylated miR-27a. We provide evidence that TUMR expands the targets of other endogenous miRNAs. Our study reveals a function of uridylated isomiRs in regulating non-canonical miRNA targets."xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2019.05.014"xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/author | "Dai L."xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/author | "Gu S."xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/author | "Yang A."xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/author | "Jiang M."xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/author | "Shao T.J."xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/author | "Villanueva P."xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/author | "Bofill-De Ros X."xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/pages | "511-522.e4"xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/title | "3' Uridylation Confers miRNAs with Non-canonical Target Repertoires."xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/31178353 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31178353 |
| http://purl.uniprot.org/citations/31178353 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31178353 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DFM7-mappedCitation-31178353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31178353 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DFW3-mappedCitation-31178353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31178353 |
| http://purl.uniprot.org/uniprot/#_Q5VYS8-mappedCitation-31178353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31178353 |
| http://purl.uniprot.org/uniprot/#_Q5TAX3-mappedCitation-31178353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31178353 |
| http://purl.uniprot.org/uniprot/#_Q96KX5-mappedCitation-31178353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31178353 |
| http://purl.uniprot.org/uniprot/#_X6R3Q3-mappedCitation-31178353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31178353 |
| http://purl.uniprot.org/uniprot/A0A0C4DFW3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31178353 |