| http://purl.uniprot.org/citations/31182604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31182604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31182604 | http://www.w3.org/2000/01/rdf-schema#comment | "Noroviruses are a leading cause of foodborne illnesses worldwide. Although GII.4 strains have been responsible for most norovirus outbreaks, the assembled virus shell structures have been available in detail for only a single strain (GI.1). We present high-resolution (2.6-to 4.1-Å) cryoelectron microscopy (cryo-EM) structures of GII.4, GII.2, GI.7, and GI.1 human norovirus outbreak strain virus-like particles (VLPs). Although norovirus VLPs have been thought to exist in a single-sized assembly, our structures reveal polymorphism between and within genogroups, with small, medium, and large particle sizes observed. Using asymmetric reconstruction, we were able to resolve a Zn2+ metal ion adjacent to the coreceptor binding site, which affected the structural stability of the shell. Our structures serve as valuable templates for facilitating vaccine formulations."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1903562116"xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1903562116"xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/author | "Grigorieff N."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/author | "Grigorieff N."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/author | "Joshua-Tor L."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/author | "Joshua-Tor L."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/author | "Jung J."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/author | "Jung J."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/author | "Grant T."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/author | "Grant T."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/author | "Thomas D.R."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/author | "Thomas D.R."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/author | "Diehnelt C.W."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/author | "Diehnelt C.W."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/pages | "12828-12832"xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/pages | "12828-12832"xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/title | "High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations."xsd:string |
| http://purl.uniprot.org/citations/31182604 | http://purl.uniprot.org/core/title | "High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations."xsd:string |