| http://purl.uniprot.org/citations/31185213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31185213 | http://www.w3.org/2000/01/rdf-schema#comment | "Increasing evidence demonstrates that interleukin-10 (IL-10), known as an immunosuppressive cytokine, induces antitumor effects depending on CD8+ T cells. However, it remains elusive how immunosuppressive effects of IL-10 contribute to CD8+ T cell-mediated antitumor immunity. We generated Cetuximab-based IL-10 fusion protein (CmAb-(IL10)2) to prolong its half-life and allow tumor-targeted delivery of IL-10. Our results demonstrated potent antitumor effects of CmAb-(IL10)2 with reduced toxicity. Moreover, we revealed a mechanism of CmAb-(IL10)2 preventing dendritic cell (DC)-mediated CD8+ tumor-infiltrating lymphocyte apoptosis through regulating IFN-γ production. When combined with immune checkpoint blockade, CmAb-(IL10)2 significantly improves antitumor effects in mice with advanced tumors. Our findings reveal a DC-regulating role of IL-10 to potentiate CD8+ T cell-mediated antitumor immunity and provide a potential strategy to improve cancer immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2019.05.005"xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Han C."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Xu T."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Zhang A."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Moore C."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Fu K."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Ren Z."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Qiao J."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Fu Y.X."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/author | "Luan Y."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/pages | "901-915.e4"xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/title | "Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8+ T Cell Apoptosis."xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/31185213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31185213 |
| http://purl.uniprot.org/citations/31185213 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31185213 |
| http://purl.uniprot.org/uniprot/#_A0A1L1ST40-mappedCitation-31185213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31185213 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SUX8-mappedCitation-31185213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31185213 |