| http://purl.uniprot.org/citations/31185214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31185214 | http://www.w3.org/2000/01/rdf-schema#comment | "Diffuse large B cell lymphomas (DLBCLs) are genetically heterogeneous and highly proliferative neoplasms derived from germinal center (GC) B cells. Here, we show that DLBCLs are dependent on mitochondrial lysine deacetylase SIRT3 for proliferation, survival, self-renewal, and tumor growth in vivo regardless of disease subtype and genetics. SIRT3 knockout attenuated B cell lymphomagenesis in VavP-Bcl2 mice without affecting normal GC formation. Mechanistically, SIRT3 depletion impaired glutamine flux to the TCA cycle via glutamate dehydrogenase and reduction in acetyl-CoA pools, which in turn induce autophagy and cell death. We developed a mitochondrial-targeted class I sirtuin inhibitor, YC8-02, which phenocopied the effects of SIRT3 depletion and killed DLBCL cells. SIRT3 is thus a metabolic non-oncogene addiction and therapeutic target for DLBCLs."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2019.05.002"xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Chiang Y.L."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Cantley L.C."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Hu J."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Jing H."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Lin H."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Hong J.Y."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Shen H."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Green M.R."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Cross J.R."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Jain N."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Cerchietti L."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Lyssiotis C.A."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Melnick A.M."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Duy C."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Mistry S.J."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/author | "Teater M.R."xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/31185214 | http://purl.uniprot.org/core/pages | "916-931.e9"xsd:string |