| http://purl.uniprot.org/citations/31189111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31189111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31189111 | http://www.w3.org/2000/01/rdf-schema#comment | "A species barrier for the influenza A virus is the differential expression of sialic acid, which can either be α2,3-linked for avians or α2,6-linked for human viruses. The influenza A virus hosts also express other species-specific sialic acid derivatives. One major modification at C-5 is N-glycolyl (NeuGc), instead of N-acetyl (NeuAc). N-glycolyl is mammalian specific and expressed in pigs and horses, but not in humans, ferrets, seals, or dogs. Hemagglutinin (HA) adaptation to either N-acetyl or N-glycolyl is analyzed on a sialoside microarray containing both α2,3- and α2,6-linkage modifications on biologically relevant N-glycans. Binding studies reveal that avian, human, and equine HAs bind either N-glycolyl or N-acetyl. Structural data on N-glycolyl binding HA proteins of both H5 and H7 origin describe this specificity. Neuraminidases can cleave N-glycolyl efficiently, and tissue-binding studies reveal strict species specificity. The exclusive manner in which influenza A viruses differentiate between N-glycolyl and N-acetyl is indicative of selection."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.05.048"xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.05.048"xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Garcia-Sastre A."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Garcia-Sastre A."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Yu W."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Yu W."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "de Vries R.P."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "de Vries R.P."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Papanikolaou A."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Papanikolaou A."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Wennekes T."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Wennekes T."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Martinez-Romero C."xsd:string |
| http://purl.uniprot.org/citations/31189111 | http://purl.uniprot.org/core/author | "Martinez-Romero C."xsd:string |