| http://purl.uniprot.org/citations/31205021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31205021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31205021 | http://www.w3.org/2000/01/rdf-schema#comment | "The equilibrium between phosphorylation and dephosphorylation is one of the most important processes that takes place in living cells. Human phosphoserine phosphatase (hPSP) is a key enzyme in the production of serine by the dephosphorylation of phospho-L-serine. It is directly involved in the biosynthesis of other important metabolites such as glycine and D-serine (a neuromodulator). hPSP is involved in the survival mechanism of cancer cells and has recently been found to be an essential biomarker. Here, three new high-resolution crystal structures of hPSP (1.5-2.0 Å) in complexes with phosphoserine and with serine, which are the substrate and the product of the reaction, respectively, and in complex with a noncleavable substrate analogue (homocysteic acid) are presented. New types of interactions take place between the enzyme and its ligands. Moreover, the loop involved in the open/closed state of the enzyme is fully refined in a totally unfolded conformation. This loop is further studied through molecular-dynamics simulations. Finally, all of these analyses allow a more complete reaction mechanism for this enzyme to be proposed which is consistent with previous publications on the subject."xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.org/dc/terms/identifier | "doi:10.1107/s2059798319006867"xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.org/dc/terms/identifier | "doi:10.1107/s2059798319006867"xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/author | "Wouters J."xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/author | "Wouters J."xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/author | "Leherte L."xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/author | "Leherte L."xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/author | "Haufroid M."xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/author | "Haufroid M."xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/author | "Mirgaux M."xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/author | "Mirgaux M."xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/name | "Acta Crystallogr. D"xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/name | "Acta Crystallogr. D"xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/pages | "592-604"xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/pages | "592-604"xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/title | "Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase."xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/title | "Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase."xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/31205021 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31205021 |
| http://purl.uniprot.org/citations/31205021 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31205021 |