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Aim

This study aimed to investigate the possible functions of interaction between JARID1B and miR-137 in ALL.

Methods

The levels of H3K4me3 and H3K4me2 and the expression of JARID1B and miR-137 were analyzed in six ALL cell lines and 30 ALL patients. The effects of miR-137 and JARID1B on cell proliferation and apoptosis were investigated by silencing or promoting the respective genes. The interaction between miR-137 and JARID1B was confirmed by double-luciferase report assay.

Results

The histone H3K4 expressions and miR-137 expression were lower in 30 ALL patients and in six ALL cell lines, while the expression of JARID1B was elevated. A negative correlation was observed between JARID1B and miR-137. Over-expression of miR-137 led to decreasing cell proliferation and increasing apoptosis in MOLT-4 and BALL-1 cells. MiR-137 inhibitor up-regulated JARID1B in these two cell lines, while promoted proliferation in BALL-1 cells only. Dual-luciferase report assay suggested that JARID1B was a direct target of miR-137 in ALL cell lines.

Conclusions

The expression of miR-137 was declined in ALL, and JARID1B was directly repressed by miR-137. Aberrant JARID1B expression could result in abnormal histone methylation, which might be one cause of ALL."xsd:string
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http://purl.uniprot.org/citations/31206203http://purl.uniprot.org/core/author"Ma X."xsd:string
http://purl.uniprot.org/citations/31206203http://purl.uniprot.org/core/author"Zheng R."xsd:string
http://purl.uniprot.org/citations/31206203http://purl.uniprot.org/core/author"Zou Y."xsd:string
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http://purl.uniprot.org/citations/31206203http://purl.uniprot.org/core/title"MiR-137 inhibits cell proliferation in acute lymphoblastic leukemia by targeting JARID1B."xsd:string
http://purl.uniprot.org/citations/31206203http://purl.uniprot.org/core/volume"103"xsd:string
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